diff --git a/pkg/specgen/generate/storage.go b/pkg/specgen/generate/storage.go
index 7703e90815..a79a6cf6b2 100644
--- a/pkg/specgen/generate/storage.go
+++ b/pkg/specgen/generate/storage.go
@@ -157,6 +157,12 @@ func finalizeMounts(ctx context.Context, s *specgen.SpecGenerator, rt *libpod.Ru
 		delete(baseMounts, dest)
 	}
 
+	// Overlays are neither mounts nor volumes but should supersede both.
+	for dest := range unifiedOverlays {
+		delete(baseVolumes, dest)
+		delete(baseMounts, dest)
+	}
+
 	// Supersede volumes-from/image volumes with unified volumes from above.
 	// This is an unconditional replacement.
 	for dest, mount := range unifiedMounts {
@@ -169,16 +175,22 @@ func finalizeMounts(ctx context.Context, s *specgen.SpecGenerator, rt *libpod.Ru
 	// TODO: Investigate moving readonlyTmpfs into here. Would be more
 	// correct.
 
-	// Check for conflicts between named volumes and mounts
+	// Check for conflicts between named volumes, mounts, and overlays
 	for dest := range baseMounts {
 		if _, ok := baseVolumes[dest]; ok {
 			return nil, nil, nil, fmt.Errorf("baseMounts conflict at mount destination %v: %w", dest, specgen.ErrDuplicateDest)
 		}
+		if _, ok := unifiedOverlays[dest]; ok {
+			return nil, nil, nil, fmt.Errorf("baseMounts conflict with overlay mount at mount destination %v: %w", dest, specgen.ErrDuplicateDest)
+		}
 	}
 	for dest := range baseVolumes {
 		if _, ok := baseMounts[dest]; ok {
 			return nil, nil, nil, fmt.Errorf("baseVolumes conflict at mount destination %v: %w", dest, specgen.ErrDuplicateDest)
 		}
+		if _, ok := unifiedOverlays[dest]; ok {
+			return nil, nil, nil, fmt.Errorf("baseVolumes conflict with overlay mount at mount destination %v: %w", dest, specgen.ErrDuplicateDest)
+		}
 	}
 
 	if s.ReadWriteTmpfs != nil && *s.ReadWriteTmpfs {
diff --git a/test/e2e/run_volume_test.go b/test/e2e/run_volume_test.go
index 6f184c3218..b14ca83cc4 100644
--- a/test/e2e/run_volume_test.go
+++ b/test/e2e/run_volume_test.go
@@ -139,6 +139,10 @@ var _ = Describe("Podman run with volumes", func() {
 		session := podmanTest.Podman([]string{"run", "-v", mountPath + ":" + dest, "-v", "/tmp" + ":" + dest, ALPINE, "ls"})
 		session.WaitWithDefaultTimeout()
 		Expect(session).Should(ExitWithError(125, fmt.Sprintf("%s: duplicate mount destination", dest)))
+
+		session = podmanTest.Podman([]string{"run", "-v", "myvol:" + dest, "-v", mountPath + ":" + dest + ":O", ALPINE, "ls", "/test"})
+		session.WaitWithDefaultTimeout()
+		Expect(session).To(ExitWithError(125, fmt.Sprintf("%s: duplicate mount destination", dest)))
 	})
 
 	It("podman run with conflict between image volume and user mount succeeds", func() {
@@ -1089,4 +1093,20 @@ RUN chmod 755 /test1 /test2 /test3`, ALPINE)
 		Expect(checkCtr.OutputToString()).To(ContainSubstring("foo"))
 		Expect(checkCtr.OutputToString()).To(ContainSubstring("bar"))
 	})
+
+	It("user-specified overlay supersedes image volume", func() {
+		err := podmanTest.RestoreArtifact(REDIS_IMAGE)
+		Expect(err).ToNot(HaveOccurred())
+		mountPath := filepath.Join(podmanTest.TempDir, "secrets")
+		err = os.Mkdir(mountPath, 0755)
+		Expect(err).ToNot(HaveOccurred())
+		testFile := filepath.Join(mountPath, "test1")
+		f, err := os.Create(testFile)
+		Expect(err).ToNot(HaveOccurred(), "os.Create(testfile)")
+		f.Close()
+		Expect(err).ToNot(HaveOccurred())
+		session := podmanTest.Podman([]string{"run", "-v", fmt.Sprintf("%s:/data:O", mountPath), REDIS_IMAGE, "ls", "/data/test1"})
+		session.WaitWithDefaultTimeout()
+		Expect(session).Should(ExitCleanly())
+	})
 })