diff --git a/pkg/specgen/generate/oci.go b/pkg/specgen/generate/oci.go
index 1a0ec08a58..eefe45dfe7 100644
--- a/pkg/specgen/generate/oci.go
+++ b/pkg/specgen/generate/oci.go
@@ -105,7 +105,10 @@ func makeCommand(ctx context.Context, s *specgen.SpecGenerator, img *image.Image
 		entrypoint = newEntry
 	}
 
-	finalCommand = append(finalCommand, entrypoint...)
+	// Don't append the entrypoint if it is [""]
+	if len(entrypoint) != 1 || entrypoint[0] != "" {
+		finalCommand = append(finalCommand, entrypoint...)
+	}
 
 	// Only use image command if the user did not manually set an
 	// entrypoint.
diff --git a/test/e2e/run_entrypoint_test.go b/test/e2e/run_entrypoint_test.go
index cac3d759d0..389f142b1f 100644
--- a/test/e2e/run_entrypoint_test.go
+++ b/test/e2e/run_entrypoint_test.go
@@ -43,6 +43,18 @@ CMD []
 		Expect(session.ExitCode()).To(Equal(125))
 	})
 
+	It("podman run entrypoint == [\"\"]", func() {
+		dockerfile := `FROM quay.io/libpod/alpine:latest
+ENTRYPOINT [""]
+CMD []
+`
+		podmanTest.BuildImage(dockerfile, "foobar.com/entrypoint:latest", "false")
+		session := podmanTest.Podman([]string{"run", "foobar.com/entrypoint:latest", "echo", "hello"})
+		session.WaitWithDefaultTimeout()
+		Expect(session.ExitCode()).To(Equal(0))
+		Expect(session.OutputToString()).To(Equal("hello"))
+	})
+
 	It("podman run entrypoint", func() {
 		dockerfile := `FROM quay.io/libpod/alpine:latest
 ENTRYPOINT ["grep", "Alpine", "/etc/os-release"]