diff --git a/opentelemetry-instrumentation/MANIFEST.in b/opentelemetry-instrumentation/MANIFEST.in
deleted file mode 100644
index faee27714..000000000
--- a/opentelemetry-instrumentation/MANIFEST.in
+++ /dev/null
@@ -1,8 +0,0 @@
-graft src
-graft tests
-global-exclude *.pyc
-global-exclude *.pyo
-global-exclude __pycache__/*
-include MANIFEST.in
-include README.rst
-include LICENSE
diff --git a/opentelemetry-instrumentation/pyproject.toml b/opentelemetry-instrumentation/pyproject.toml
new file mode 100644
index 000000000..6d219f642
--- /dev/null
+++ b/opentelemetry-instrumentation/pyproject.toml
@@ -0,0 +1,55 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
+[project]
+name = "opentelemetry-instrumentation"
+dynamic = ["version"]
+description = "Instrumentation Tools & Auto Instrumentation for OpenTelemetry Python"
+readme = "README.rst"
+license = "Apache-2.0"
+requires-python = ">=3.7"
+authors = [
+  { name = "OpenTelemetry Authors", email = "cncf-opentelemetry-contributors@lists.cncf.io" },
+]
+classifiers = [
+  "Development Status :: 4 - Beta",
+  "Intended Audience :: Developers",
+  "License :: OSI Approved :: Apache Software License",
+  "Programming Language :: Python",
+  "Programming Language :: Python :: 3",
+  "Programming Language :: Python :: 3.7",
+  "Programming Language :: Python :: 3.8",
+  "Programming Language :: Python :: 3.9",
+  "Programming Language :: Python :: 3.10",
+]
+dependencies = [
+  "opentelemetry-api ~= 1.4",
+  "setuptools >= 16.0",
+  "wrapt >= 1.0.0, < 2.0.0",
+]
+
+[project.optional-dependencies]
+test = []
+
+[project.scripts]
+opentelemetry-bootstrap = "opentelemetry.instrumentation.bootstrap:run"
+opentelemetry-instrument = "opentelemetry.instrumentation.auto_instrumentation:run"
+
+[project.entry-points.opentelemetry_environment_variables]
+instrumentation = "opentelemetry.instrumentation.environment_variables"
+
+[project.urls]
+Homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/opentelemetry-instrumentation"
+
+[tool.hatch.version]
+path = "src/opentelemetry/instrumentation/version.py"
+
+[tool.hatch.build.targets.sdist]
+include = [
+  "/src",
+  "/tests",
+]
+
+[tool.hatch.build.targets.wheel]
+packages = ["src/opentelemetry"]
diff --git a/opentelemetry-instrumentation/setup.cfg b/opentelemetry-instrumentation/setup.cfg
deleted file mode 100644
index fcbde9b50..000000000
--- a/opentelemetry-instrumentation/setup.cfg
+++ /dev/null
@@ -1,59 +0,0 @@
-# Copyright The OpenTelemetry Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-#
-[metadata]
-name = opentelemetry-instrumentation
-description = Instrumentation Tools & Auto Instrumentation for OpenTelemetry Python
-long_description = file: README.rst
-long_description_content_type = text/x-rst
-author = OpenTelemetry Authors
-author_email = cncf-opentelemetry-contributors@lists.cncf.io
-url = https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/opentelemetry-instrumentation
-platforms = any
-license = Apache-2.0
-classifiers =
-    Development Status :: 4 - Beta
-    Intended Audience :: Developers
-    License :: OSI Approved :: Apache Software License
-    Programming Language :: Python
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.7
-    Programming Language :: Python :: 3.8
-    Programming Language :: Python :: 3.9
-    Programming Language :: Python :: 3.10
-
-[options]
-python_requires = >=3.7
-package_dir=
-    =src
-packages=find_namespace:
-zip_safe = False
-include_package_data = True
-install_requires =
-    opentelemetry-api ~= 1.4
-    setuptools >= 16.0
-    wrapt >= 1.0.0, < 2.0.0
-
-[options.packages.find]
-where = src
-
-[options.entry_points]
-console_scripts =
-    opentelemetry-instrument = opentelemetry.instrumentation.auto_instrumentation:run
-    opentelemetry-bootstrap = opentelemetry.instrumentation.bootstrap:run
-opentelemetry_environment_variables =
-    instrumentation = opentelemetry.instrumentation.environment_variables
-
-[options.extras_require]
-test =
diff --git a/opentelemetry-instrumentation/setup.py b/opentelemetry-instrumentation/setup.py
deleted file mode 100644
index 9d1d5b7b0..000000000
--- a/opentelemetry-instrumentation/setup.py
+++ /dev/null
@@ -1,29 +0,0 @@
-# Copyright The OpenTelemetry Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-
-import os
-
-import setuptools
-
-BASE_DIR = os.path.dirname(__file__)
-VERSION_FILENAME = os.path.join(
-    BASE_DIR, "src", "opentelemetry", "instrumentation", "version.py"
-)
-PACKAGE_INFO = {}
-with open(VERSION_FILENAME, encoding="utf-8") as f:
-    exec(f.read(), PACKAGE_INFO)
-
-setuptools.setup(
-    version=PACKAGE_INFO["__version__"],
-)