diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py b/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py
index fe74e2323..f43f103d2 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py
@@ -1,4 +1,4 @@
-# Copyright 2020, OpenTelemetry Authors
+# Copyright The OpenTelemetry Authors
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/setup.py b/instrumentation/opentelemetry-instrumentation-aiopg/setup.py
index dfd463e5a..882d311bb 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/setup.py b/instrumentation/opentelemetry-instrumentation-asgi/setup.py
index 3369352fe..baef56515 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py b/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py
index 2ad47ac9d..73ea9171e 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-boto/setup.py b/instrumentation/opentelemetry-instrumentation-boto/setup.py
index 2bd68894f..fd58c052d 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-boto/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/setup.py b/instrumentation/opentelemetry-instrumentation-botocore/setup.py
index fd5045efa..ae361301e 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-botocore/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-celery/setup.py b/instrumentation/opentelemetry-instrumentation-celery/setup.py
index ca6793066..4c86fe4d1 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-celery/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/setup.py b/instrumentation/opentelemetry-instrumentation-dbapi/setup.py
index cfe98f389..9c0a175c5 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-django/setup.py b/instrumentation/opentelemetry-instrumentation-django/setup.py
index fb9d615ce..71984838d 100644
--- a/instrumentation/opentelemetry-instrumentation-django/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-django/setup.py
@@ -12,21 +12,21 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-from os.path import dirname, join
 
-from setuptools import setup
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
 
+
+import os
+
+import setuptools
+
+BASE_DIR = os.path.dirname(__file__)
+VERSION_FILENAME = os.path.join(
+    BASE_DIR, "src", "opentelemetry", "instrumentation", "django", "version.py"
+)
 PACKAGE_INFO = {}
-with open(
-    join(
-        dirname(__file__),
-        "src",
-        "opentelemetry",
-        "instrumentation",
-        "django",
-        "version.py",
-    )
-) as f:
+with open(VERSION_FILENAME) as f:
     exec(f.read(), PACKAGE_INFO)
 
-setup(version=PACKAGE_INFO["__version__"])
+setuptools.setup(version=PACKAGE_INFO["__version__"])
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py b/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py
index cd7a7f101..90e3144fb 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/setup.py b/instrumentation/opentelemetry-instrumentation-falcon/setup.py
index eb61edde6..5be5b53de 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/setup.py b/instrumentation/opentelemetry-instrumentation-fastapi/setup.py
index 13c7c5a99..fbeb3bcc3 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-flask/setup.cfg b/instrumentation/opentelemetry-instrumentation-flask/setup.cfg
index 93f88db73..6b6fe2bd6 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-flask/setup.cfg
@@ -50,5 +50,9 @@ test =
     flask~=1.0
     opentelemetry-test == 0.21.dev0
 
+[options.entry_points]
+opentelemetry_instrumentor =
+    flask = opentelemetry.instrumentation.flask:FlaskInstrumentor
+
 [options.packages.find]
 where = src
diff --git a/instrumentation/opentelemetry-instrumentation-flask/setup.py b/instrumentation/opentelemetry-instrumentation-flask/setup.py
index 587b697a7..6aa448f33 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
@@ -23,11 +29,4 @@ PACKAGE_INFO = {}
 with open(VERSION_FILENAME) as f:
     exec(f.read(), PACKAGE_INFO)
 
-setuptools.setup(
-    version=PACKAGE_INFO["__version__"],
-    entry_points={
-        "opentelemetry_instrumentor": [
-            "flask = opentelemetry.instrumentation.flask:FlaskInstrumentor"
-        ]
-    },
-)
+setuptools.setup(version=PACKAGE_INFO["__version__"])
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/setup.py b/instrumentation/opentelemetry-instrumentation-grpc/setup.py
index 87c720aea..4002e4ac1 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/setup.py
@@ -12,6 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/setup.py b/instrumentation/opentelemetry-instrumentation-jinja2/setup.py
index e9d484e1e..34d5af44e 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-logging/setup.py b/instrumentation/opentelemetry-instrumentation-logging/setup.py
index 3bebc496e..7521827f2 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-logging/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/setup.py b/instrumentation/opentelemetry-instrumentation-mysql/setup.py
index 955f75d71..f133f24b4 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-mysql/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py b/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py
index 4bd0e16be..c2cf7dbb6 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
index 46bf60793..d1b5d39fb 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
@@ -11,7 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
-#
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/setup.py b/instrumentation/opentelemetry-instrumentation-pymongo/setup.py
index 7b862ae2a..aed252425 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/setup.py b/instrumentation/opentelemetry-instrumentation-pymysql/setup.py
index 74cd948fe..9b739bc4a 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/setup.py b/instrumentation/opentelemetry-instrumentation-pyramid/setup.py
index 7141a8981..ba4a44f1f 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-redis/setup.py b/instrumentation/opentelemetry-instrumentation-redis/setup.py
index df80a8fd1..f8cb327d3 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-redis/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-requests/setup.py b/instrumentation/opentelemetry-instrumentation-requests/setup.py
index 237fef583..8cecfc9f9 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-requests/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-sklearn/setup.py b/instrumentation/opentelemetry-instrumentation-sklearn/setup.py
index 92f53925e..c3ac3f30c 100644
--- a/instrumentation/opentelemetry-instrumentation-sklearn/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-sklearn/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py
index 26d3ef4fc..943a8347f 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py b/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py
index 67ce350fa..177a75a63 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/setup.py b/instrumentation/opentelemetry-instrumentation-starlette/setup.py
index 0232a6f44..97895bb97 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-starlette/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg b/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg
index 071eabdb1..217aa6cf7 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg
@@ -48,5 +48,9 @@ test =
     tornado >= 6.0
     opentelemetry-test == 0.21.dev0
 
+[options.entry_points]
+opentelemetry_instrumentor =
+    tornado = opentelemetry.instrumentation.tornado:TornadoInstrumentor
+
 [options.packages.find]
 where = src
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/setup.py b/instrumentation/opentelemetry-instrumentation-tornado/setup.py
index bd6814b50..6cbbe447f 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
@@ -28,11 +34,4 @@ PACKAGE_INFO = {}
 with open(VERSION_FILENAME) as f:
     exec(f.read(), PACKAGE_INFO)
 
-setuptools.setup(
-    version=PACKAGE_INFO["__version__"],
-    entry_points={
-        "opentelemetry_instrumentor": [
-            "tornado = opentelemetry.instrumentation.tornado:TornadoInstrumentor"
-        ]
-    },
-)
+setuptools.setup(version=PACKAGE_INFO["__version__"])
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/setup.py b/instrumentation/opentelemetry-instrumentation-urllib/setup.py
index 33c068c69..7fb18f134 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-urllib/setup.py
@@ -11,18 +11,19 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
 
 BASE_DIR = os.path.dirname(__file__)
 VERSION_FILENAME = os.path.join(
-    BASE_DIR,
-    "src",
-    "opentelemetry",
-    "instrumentation",
-    "urllib",
-    "version.py",
+    BASE_DIR, "src", "opentelemetry", "instrumentation", "urllib", "version.py"
 )
 PACKAGE_INFO = {}
 with open(VERSION_FILENAME) as f:
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/setup.py b/instrumentation/opentelemetry-instrumentation-urllib3/setup.py
index fe391cb46..d0bc82257 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/setup.py b/instrumentation/opentelemetry-instrumentation-wsgi/setup.py
index fb4ffa743..ac2077cbe 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/setup.py
@@ -11,6 +11,12 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
+
+
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+
+
 import os
 
 import setuptools
diff --git a/scripts/generate_setup.py b/scripts/generate_setup.py
new file mode 100644
index 000000000..8890fac67
--- /dev/null
+++ b/scripts/generate_setup.py
@@ -0,0 +1,77 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import logging
+import os
+import subprocess
+
+from jinja2 import Template
+
+logging.basicConfig(level=logging.INFO)
+logger = logging.getLogger("setupy_generator")
+
+_auto_generation_msg = """
+# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/{source}.
+# RUN `python scripts/generate_setup.py` TO REGENERATE.
+"""
+_template_dir = "templates"
+_template_name = "instrumentation_setup.py.txt"
+_prefix = "opentelemetry-instrumentation-"
+
+
+def main():
+    root_path = os.path.dirname(os.path.dirname(os.path.abspath(__file__)))
+    setuppy_tmpl = Template(
+        open(
+            os.path.join(root_path, _template_dir, _template_name), "r"
+        ).read()
+    )
+    base_instrumentation_path = os.path.join(root_path, "instrumentation")
+
+    for instrumentation in os.listdir(base_instrumentation_path):
+        instrumentation_path = os.path.join(
+            base_instrumentation_path, instrumentation
+        )
+        if not os.path.isdir(
+            instrumentation_path
+        ) or not instrumentation.startswith(_prefix):
+            continue
+
+        src_dir = os.path.join(
+            instrumentation_path, "src", "opentelemetry", "instrumentation"
+        )
+        src_pkgs = [
+            f
+            for f in os.listdir(src_dir)
+            if os.path.isdir(os.path.join(src_dir, f))
+        ]
+        assert len(src_pkgs) == 1
+        name = src_pkgs[0]
+        generated = setuppy_tmpl.render(
+            name=name,
+            auto_generation_msg=_auto_generation_msg.format(
+                source=_template_name
+            ),
+        )
+
+        generated_file = os.path.join(instrumentation_path, "setup.py")
+        logger.info("generated %s", generated_file)
+        with open(generated_file, "w") as fh:
+            fh.write(generated)
+            fh.flush()
+        subprocess.run(["black", "-q", generated_file], check=True)
+
+
+if __name__ == "__main__":
+    main()
diff --git a/templates/instrumentation_setup.py.txt b/templates/instrumentation_setup.py.txt
new file mode 100644
index 000000000..b619c49b5
--- /dev/null
+++ b/templates/instrumentation_setup.py.txt
@@ -0,0 +1,36 @@
+
+
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+{{ auto_generation_msg }}
+
+import os
+
+import setuptools
+
+BASE_DIR = os.path.dirname(__file__)
+VERSION_FILENAME = os.path.join(
+    BASE_DIR,
+    "src",
+    "opentelemetry",
+    "instrumentation",
+    "{{ name }}",
+    "version.py"
+)
+PACKAGE_INFO = {}
+with open(VERSION_FILENAME) as f:
+    exec(f.read(), PACKAGE_INFO)
+
+setuptools.setup(version=PACKAGE_INFO["__version__"])
\ No newline at end of file