diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/MANIFEST.IN b/instrumentation/opentelemetry-instrumentation-pymemcache/MANIFEST.IN
deleted file mode 100644
index aed3e3327..000000000
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/MANIFEST.IN
+++ /dev/null
@@ -1,9 +0,0 @@
-graft src
-graft tests
-global-exclude *.pyc
-global-exclude *.pyo
-global-exclude __pycache__/*
-include CHANGELOG.md
-include MANIFEST.in
-include README.rst
-include LICENSE
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
new file mode 100644
index 000000000..8e76adc45
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
@@ -0,0 +1,58 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
+[project]
+name = "opentelemetry-instrumentation-pymemcache"
+dynamic = ["version"]
+description = "OpenTelemetry pymemcache instrumentation"
+readme = "README.rst"
+license = "Apache-2.0"
+requires-python = ">=3.7"
+authors = [
+  { name = "OpenTelemetry Authors", email = "cncf-opentelemetry-contributors@lists.cncf.io" },
+]
+classifiers = [
+  "Development Status :: 4 - Beta",
+  "Intended Audience :: Developers",
+  "License :: OSI Approved :: Apache Software License",
+  "Programming Language :: Python",
+  "Programming Language :: Python :: 3",
+  "Programming Language :: Python :: 3.7",
+  "Programming Language :: Python :: 3.8",
+  "Programming Language :: Python :: 3.9",
+  "Programming Language :: Python :: 3.10",
+]
+dependencies = [
+  "opentelemetry-api ~= 1.12",
+  "opentelemetry-instrumentation == 0.33b0",
+  "opentelemetry-semantic-conventions == 0.33b0",
+  "wrapt >= 1.0.0, < 2.0.0",
+]
+
+[project.optional-dependencies]
+instruments = [
+  "pymemcache >= 1.3.5, < 4",
+]
+test = [
+  "opentelemetry-instrumentation-pymemcache[instruments]",
+  "opentelemetry-test-utils == 0.33b0",
+]
+
+[project.entry-points.opentelemetry_instrumentor]
+pymemcache = "opentelemetry.instrumentation.pymemcache:PymemcacheInstrumentor"
+
+[project.urls]
+Homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/instrumentation/opentelemetry-instrumentation-pymemcache"
+
+[tool.hatch.version]
+path = "src/opentelemetry/instrumentation/pymemcache/version.py"
+
+[tool.hatch.build.targets.sdist]
+include = [
+  "/src",
+  "/tests",
+]
+
+[tool.hatch.build.targets.wheel]
+packages = ["src/opentelemetry"]
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg
deleted file mode 100644
index aeef01e67..000000000
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg
+++ /dev/null
@@ -1,56 +0,0 @@
-# Copyright The OpenTelemetry Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-#
-[metadata]
-name = opentelemetry-instrumentation-pymemcache
-description = OpenTelemetry pymemcache instrumentation
-long_description = file: README.rst
-long_description_content_type = text/x-rst
-author = OpenTelemetry Authors
-author_email = cncf-opentelemetry-contributors@lists.cncf.io
-url = https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/instrumentation/opentelemetry-instrumentation-pymemcache
-platforms = any
-license = Apache-2.0
-classifiers =
-    Development Status :: 4 - Beta
-    Intended Audience :: Developers
-    License :: OSI Approved :: Apache Software License
-    Programming Language :: Python
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.7
-    Programming Language :: Python :: 3.8
-    Programming Language :: Python :: 3.9
-    Programming Language :: Python :: 3.10
-
-[options]
-python_requires = >=3.7
-package_dir=
-    =src
-packages=find_namespace:
-install_requires =
-    opentelemetry-api ~= 1.12
-    opentelemetry-semantic-conventions == 0.33b0
-    opentelemetry-instrumentation == 0.33b0
-    wrapt >= 1.0.0, < 2.0.0
-
-[options.extras_require]
-test =
-    opentelemetry-test-utils == 0.33b0
-
-[options.packages.find]
-where = src
-
-[options.entry_points]
-opentelemetry_instrumentor =
-    pymemcache = opentelemetry.instrumentation.pymemcache:PymemcacheInstrumentor
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
deleted file mode 100644
index 105c59e9e..000000000
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
+++ /dev/null
@@ -1,99 +0,0 @@
-# Copyright The OpenTelemetry Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-
-
-# DO NOT EDIT. THIS FILE WAS AUTOGENERATED FROM templates/instrumentation_setup.py.txt.
-# RUN `python scripts/generate_setup.py` TO REGENERATE.
-
-
-import distutils.cmd
-import json
-import os
-from configparser import ConfigParser
-
-import setuptools
-
-config = ConfigParser()
-config.read("setup.cfg")
-
-# We provide extras_require parameter to setuptools.setup later which
-# overwrites the extras_require section from setup.cfg. To support extras_require
-# section in setup.cfg, we load it here and merge it with the extras_require param.
-extras_require = {}
-if "options.extras_require" in config:
-    for key, value in config["options.extras_require"].items():
-        extras_require[key] = [v for v in value.split("\n") if v.strip()]
-
-BASE_DIR = os.path.dirname(__file__)
-PACKAGE_INFO = {}
-
-VERSION_FILENAME = os.path.join(
-    BASE_DIR,
-    "src",
-    "opentelemetry",
-    "instrumentation",
-    "pymemcache",
-    "version.py",
-)
-with open(VERSION_FILENAME, encoding="utf-8") as f:
-    exec(f.read(), PACKAGE_INFO)
-
-PACKAGE_FILENAME = os.path.join(
-    BASE_DIR,
-    "src",
-    "opentelemetry",
-    "instrumentation",
-    "pymemcache",
-    "package.py",
-)
-with open(PACKAGE_FILENAME, encoding="utf-8") as f:
-    exec(f.read(), PACKAGE_INFO)
-
-# Mark any instruments/runtime dependencies as test dependencies as well.
-extras_require["instruments"] = PACKAGE_INFO["_instruments"]
-test_deps = extras_require.get("test", [])
-for dep in extras_require["instruments"]:
-    test_deps.append(dep)
-
-extras_require["test"] = test_deps
-
-
-class JSONMetadataCommand(distutils.cmd.Command):
-
-    description = (
-        "print out package metadata as JSON. This is used by OpenTelemetry dev scripts to ",
-        "auto-generate code in other places",
-    )
-    user_options = []
-
-    def initialize_options(self):
-        pass
-
-    def finalize_options(self):
-        pass
-
-    def run(self):
-        metadata = {
-            "name": config["metadata"]["name"],
-            "version": PACKAGE_INFO["__version__"],
-            "instruments": PACKAGE_INFO["_instruments"],
-        }
-        print(json.dumps(metadata))
-
-
-setuptools.setup(
-    cmdclass={"meta": JSONMetadataCommand},
-    version=PACKAGE_INFO["__version__"],
-    extras_require=extras_require,
-)