diff --git a/CHANGELOG.md b/CHANGELOG.md
index 51c1880f6..aa3f9704d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,8 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/),
 and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html).
 
 ## [Unreleased](https://github.com/open-telemetry/opentelemetry-python/compare/v1.3.0-0.22b0...HEAD)
+- Include Flask 2.0 as compatible with existing flask instrumentation
+  ([#545](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/545))
 
 ### Changed
 - `opentelemetry-instrumentation-tornado` properly instrument work done in tornado on_finish method.
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/package.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/package.py
index eaa1ed37f..b08156420 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/package.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/package.py
@@ -13,4 +13,4 @@
 # limitations under the License.
 
 
-_instruments = ("flask ~= 1.0",)
+_instruments = ("flask >= 1.0, < 3.0",)
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index 5e747136a..5d6694acd 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -61,7 +61,7 @@ libraries = {
         "instrumentation": "opentelemetry-instrumentation-fastapi==0.23.dev0",
     },
     "flask": {
-        "library": "flask ~= 1.0",
+        "library": "flask >= 1.0, < 3.0",
         "instrumentation": "opentelemetry-instrumentation-flask==0.23.dev0",
     },
     "grpcio": {