diff --git a/CHANGELOG.md b/CHANGELOG.md
index d946d825d..05d3b3900 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -11,6 +11,18 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+### Fixed
+
+- `opentelemetry-instrumentation`: Fix dependency conflict detection when instrumented packages are not installed by moving check back to before instrumentors are loaded. Add "instruments-any" feature for instrumentations that target multiple packages.
+  ([#3610](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3610))
+
+### Added
+
+- `opentelemetry-instrumentation-psycopg2` Utilize instruments-any functionality.
+  ([#3610](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3610))
+- `opentelemetry-instrumentation-kafka-python` Utilize instruments-any functionality.
+  ([#3610](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3610))
+
 ## Version 1.35.0/0.56b0 (2025-07-11)
 
 ### Added
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index 3e2283a66..1057ad4e9 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -325,10 +325,25 @@ Below is a checklist of things to be mindful of when implementing a new instrume
 ### Update supported instrumentation package versions
 
 - Navigate to the **instrumentation package directory:**
-  - Update **`pyproject.toml`** file by modifying _instruments_ entry in the `[project.optional-dependencies]` section with the new version constraint
-  - Update `_instruments` variable in instrumentation **`package.py`** file with the new version constraint
+  - Update **`pyproject.toml`** file by modifying `instruments` or `instruments-any` entry in the `[project.optional-dependencies]` section with the new version constraint
+  - Update `_instruments` or `_instruments_any` variable in instrumentation **`package.py`** file with the new version constraint
 - At the **root of the project directory**, run `tox -e generate` to regenerate necessary files
 
+Please note that `instruments-any` is an optional field that can be used instead of or in addition to `instruments`. While `instruments` is a list of dependencies, _all_ of which are expected by the instrumentation, `instruments-any` is a list _any_ of which but not all are expected. For example, the following entry requires both `util` and `common` plus either `foo` or `bar` to be present for the instrumentation to occur:
+```
+[project.optional-dependencies]
+instruments = [
+  "util ~= 1.0"
+  "common ~= 2.0"
+]
+instruments-any = [
+  "foo ~= 3.0"
+  "bar ~= 4.0"
+]
+```
+
+<!-- See https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3610 for details on instruments-any -->
+
 If you're adding support for a new version of the instrumentation package, follow these additional steps:
 
 - At the **instrumentation package directory:** Add new test-requirements.txt file with the respective package version required for testing
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
index 408232842..523c165f8 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
@@ -40,7 +40,6 @@ from opentelemetry.instrumentation.auto_instrumentation._load import (
 )
 from opentelemetry.instrumentation.dependencies import (
     DependencyConflict,
-    DependencyConflictError,
 )
 from opentelemetry.sdk.metrics.export import (
     HistogramDataPoint,
@@ -1102,40 +1101,34 @@ class TestAutoInstrumentation(TestBaseAutoFastAPI):
             [self._instrumentation_loaded_successfully_call()]
         )
 
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch("opentelemetry.instrumentation.auto_instrumentation._load._logger")
-    def test_instruments_with_old_fastapi_installed(self, mock_logger):  # pylint: disable=no-self-use
+    def test_instruments_with_old_fastapi_installed(
+        self, mock_logger, mock_dep
+    ):  # pylint: disable=no-self-use
         dependency_conflict = DependencyConflict("0.58", "0.57")
         mock_distro = Mock()
-        mock_distro.load_instrumentor.side_effect = DependencyConflictError(
-            dependency_conflict
-        )
+        mock_dep.return_value = dependency_conflict
         _load_instrumentors(mock_distro)
-        self.assertEqual(len(mock_distro.load_instrumentor.call_args_list), 1)
-        (ep,) = mock_distro.load_instrumentor.call_args.args
-        self.assertEqual(ep.name, "fastapi")
-        assert (
-            self._instrumentation_loaded_successfully_call()
-            not in mock_logger.debug.call_args_list
-        )
+        mock_distro.load_instrumentor.assert_not_called()
         mock_logger.debug.assert_has_calls(
             [self._instrumentation_failed_to_load_call(dependency_conflict)]
         )
 
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch("opentelemetry.instrumentation.auto_instrumentation._load._logger")
-    def test_instruments_without_fastapi_installed(self, mock_logger):  # pylint: disable=no-self-use
+    def test_instruments_without_fastapi_installed(
+        self, mock_logger, mock_dep
+    ):  # pylint: disable=no-self-use
         dependency_conflict = DependencyConflict("0.58", None)
         mock_distro = Mock()
-        mock_distro.load_instrumentor.side_effect = DependencyConflictError(
-            dependency_conflict
-        )
+        mock_dep.return_value = dependency_conflict
         _load_instrumentors(mock_distro)
-        self.assertEqual(len(mock_distro.load_instrumentor.call_args_list), 1)
-        (ep,) = mock_distro.load_instrumentor.call_args.args
-        self.assertEqual(ep.name, "fastapi")
-        assert (
-            self._instrumentation_loaded_successfully_call()
-            not in mock_logger.debug.call_args_list
-        )
+        mock_distro.load_instrumentor.assert_not_called()
         mock_logger.debug.assert_has_calls(
             [self._instrumentation_failed_to_load_call(dependency_conflict)]
         )
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml b/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
index a552db42d..f9918e4d0 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
@@ -31,7 +31,8 @@ dependencies = [
 ]
 
 [project.optional-dependencies]
-instruments = [
+instruments = []
+instruments-any = [
   "kafka-python >= 2.0, < 3.0",
   "kafka-python-ng >= 2.0, < 3.0"
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/__init__.py b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/__init__.py
index c32e786b3..f1ab77e4a 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/__init__.py
@@ -91,7 +91,7 @@ from wrapt import wrap_function_wrapper
 from opentelemetry import trace
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
 from opentelemetry.instrumentation.kafka.package import (
-    _instruments,
+    _instruments_any,
     _instruments_kafka_python,
     _instruments_kafka_python_ng,
 )
@@ -123,7 +123,7 @@ class KafkaInstrumentor(BaseInstrumentor):
         except PackageNotFoundError:
             pass
 
-        return _instruments
+        return _instruments_any
 
     def _instrument(self, **kwargs):
         """Instruments the kafka module
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/package.py b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/package.py
index 3a4a5e5de..682eeb474 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/package.py
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/package.py
@@ -16,4 +16,5 @@
 _instruments_kafka_python = "kafka-python >= 2.0, < 3.0"
 _instruments_kafka_python_ng = "kafka-python-ng >= 2.0, < 3.0"
 
-_instruments = (_instruments_kafka_python, _instruments_kafka_python_ng)
+_instruments = ()
+_instruments_any = (_instruments_kafka_python, _instruments_kafka_python_ng)
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py b/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py
index 673f347da..13587b0c3 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py
@@ -20,7 +20,6 @@ from wrapt import BoundFunctionWrapper
 
 from opentelemetry.instrumentation.kafka import KafkaInstrumentor
 from opentelemetry.instrumentation.kafka.package import (
-    _instruments,
     _instruments_kafka_python,
     _instruments_kafka_python_ng,
 )
@@ -134,4 +133,7 @@ class TestKafka(TestCase):
                 call("kafka-python"),
             ],
         )
-        self.assertEqual(package_to_instrument, _instruments)
+        self.assertEqual(
+            package_to_instrument,
+            (_instruments_kafka_python, _instruments_kafka_python_ng),
+        )
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml b/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
index 825786526..ebf55f04d 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
@@ -31,7 +31,8 @@ dependencies = [
 ]
 
 [project.optional-dependencies]
-instruments = [
+instruments = []
+instruments-any = [
   "psycopg2 >= 2.7.3.1",
   "psycopg2-binary >= 2.7.3.1",
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py
index 022c59f03..d90f894ef 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py
@@ -151,7 +151,7 @@ from psycopg2.sql import Composed  # pylint: disable=no-name-in-module
 from opentelemetry.instrumentation import dbapi
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
 from opentelemetry.instrumentation.psycopg2.package import (
-    _instruments,
+    _instruments_any,
     _instruments_psycopg2,
     _instruments_psycopg2_binary,
 )
@@ -187,7 +187,7 @@ class Psycopg2Instrumentor(BaseInstrumentor):
         except PackageNotFoundError:
             pass
 
-        return _instruments
+        return _instruments_any
 
     def _instrument(self, **kwargs):
         """Integrate with PostgreSQL Psycopg library.
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/package.py b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/package.py
index b1bf92901..1aef25432 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/package.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/package.py
@@ -16,7 +16,8 @@
 _instruments_psycopg2 = "psycopg2 >= 2.7.3.1"
 _instruments_psycopg2_binary = "psycopg2-binary >= 2.7.3.1"
 
-_instruments = (
+_instruments = ()
+_instruments_any = (
     _instruments_psycopg2,
     _instruments_psycopg2_binary,
 )
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_instrumentation.py b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_instrumentation.py
index fb707730f..93a17d9ed 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_instrumentation.py
@@ -20,7 +20,6 @@ from opentelemetry.instrumentation.auto_instrumentation._load import (
 )
 from opentelemetry.instrumentation.psycopg2 import Psycopg2Instrumentor
 from opentelemetry.instrumentation.psycopg2.package import (
-    _instruments,
     _instruments_psycopg2,
     _instruments_psycopg2_binary,
 )
@@ -130,19 +129,29 @@ class TestPsycopg2InstrumentationDependencies(TestCase):
                 call("psycopg2-binary"),
             ],
         )
-        self.assertEqual(package_to_instrument, _instruments)
+        self.assertEqual(
+            package_to_instrument,
+            (
+                _instruments_psycopg2,
+                _instruments_psycopg2_binary,
+            ),
+        )
 
     # This test is to verify that the auto instrumentation path
     # will auto instrument psycopg2 or psycopg2-binary is installed.
     # Note there is only one test here but it is run twice in tox
     # once with the psycopg2 package installed and once with
     # psycopg2-binary installed.
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch("opentelemetry.instrumentation.auto_instrumentation._load._logger")
-    def test_instruments_with_psycopg2_installed(self, mock_logger):
+    def test_instruments_with_psycopg2_installed(self, mock_logger, mock_dep):
         def _instrumentation_loaded_successfully_call():
             return call("Instrumented %s", "psycopg2")
 
         mock_distro = Mock()
+        mock_dep.return_value = None
         mock_distro.load_instrumentor.return_value = None
         _load_instrumentors(mock_distro)
         self.assertEqual(len(mock_distro.load_instrumentor.call_args_list), 1)
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
index 4bbd95b41..fb4698a72 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
@@ -12,10 +12,14 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+from functools import cached_property
 from logging import getLogger
 from os import environ
 
-from opentelemetry.instrumentation.dependencies import DependencyConflictError
+from opentelemetry.instrumentation.dependencies import (
+    DependencyConflictError,
+    get_dist_dependency_conflicts,
+)
 from opentelemetry.instrumentation.distro import BaseDistro, DefaultDistro
 from opentelemetry.instrumentation.environment_variables import (
     OTEL_PYTHON_CONFIGURATOR,
@@ -23,11 +27,36 @@ from opentelemetry.instrumentation.environment_variables import (
     OTEL_PYTHON_DISTRO,
 )
 from opentelemetry.instrumentation.version import __version__
-from opentelemetry.util._importlib_metadata import entry_points
+from opentelemetry.util._importlib_metadata import (
+    EntryPoint,
+    distributions,
+    entry_points,
+)
 
 _logger = getLogger(__name__)
 
 
+class _EntryPointDistFinder:
+    @cached_property
+    def _mapping(self):
+        return {
+            self._key_for(ep): dist
+            for dist in distributions()
+            for ep in dist.entry_points
+        }
+
+    def dist_for(self, entry_point: EntryPoint):
+        dist = getattr(entry_point, "dist", None)
+        if dist:
+            return dist
+
+        return self._mapping.get(self._key_for(entry_point))
+
+    @staticmethod
+    def _key_for(entry_point: EntryPoint):
+        return f"{entry_point.group}:{entry_point.name}:{entry_point.value}"
+
+
 def _load_distro() -> BaseDistro:
     distro_name = environ.get(OTEL_PYTHON_DISTRO, None)
     for entry_point in entry_points(group="opentelemetry_distro"):
@@ -55,6 +84,7 @@ def _load_distro() -> BaseDistro:
 
 def _load_instrumentors(distro):
     package_to_exclude = environ.get(OTEL_PYTHON_DISABLED_INSTRUMENTATIONS, [])
+    entry_point_finder = _EntryPointDistFinder()
     if isinstance(package_to_exclude, str):
         package_to_exclude = package_to_exclude.split(",")
         # to handle users entering "requests , flask" or "requests, flask" with spaces
@@ -71,11 +101,24 @@ def _load_instrumentors(distro):
             continue
 
         try:
-            distro.load_instrumentor(
-                entry_point, raise_exception_on_conflict=True
-            )
+            entry_point_dist = entry_point_finder.dist_for(entry_point)
+            conflict = get_dist_dependency_conflicts(entry_point_dist)
+            if conflict:
+                _logger.debug(
+                    "Skipping instrumentation %s: %s",
+                    entry_point.name,
+                    conflict,
+                )
+                continue
+
+            # tell instrumentation to not run dep checks again as we already did it above
+            distro.load_instrumentor(entry_point, skip_dep_check=True)
             _logger.debug("Instrumented %s", entry_point.name)
         except DependencyConflictError as exc:
+            # Dependency conflicts are generally caught from get_dist_dependency_conflicts
+            # returning a DependencyConflict. Keeping this error handling in case custom
+            # distro and instrumentor behavior raises a DependencyConflictError later.
+            # See https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3610
             _logger.debug(
                 "Skipping instrumentation %s: %s",
                 entry_point.name,
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
index 080f3553b..2460f9534 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
@@ -20,6 +20,7 @@ from typing import Collection
 from packaging.requirements import InvalidRequirement, Requirement
 
 from opentelemetry.util._importlib_metadata import (
+    Distribution,
     PackageNotFoundError,
     version,
 )
@@ -28,14 +29,44 @@ logger = getLogger(__name__)
 
 
 class DependencyConflict:
+    """Represents a dependency conflict in OpenTelemetry instrumentation.
+
+    This class is used to track conflicts between required dependencies and the
+    actual installed packages. It supports two scenarios:
+
+    1. Standard conflicts where all dependencies are required
+    2. Either/or conflicts where only one of a set of dependencies is required
+
+    Attributes:
+        required: The required dependency specification that conflicts with what's installed.
+        found: The actual dependency that was found installed (if any).
+        required_any: Collection of dependency specifications where any one would satisfy
+            the requirement (for either/or scenarios).
+        found_any: Collection of actual dependencies found for either/or scenarios.
+    """
+
     required: str | None = None
     found: str | None = None
+    # The following fields are used when an instrumentation requires any of a set of dependencies rather than all.
+    required_any: Collection[str] = None
+    found_any: Collection[str] = None
 
-    def __init__(self, required: str | None, found: str | None = None):
+    def __init__(
+        self,
+        required: str | None = None,
+        found: str | None = None,
+        required_any: Collection[str] = None,
+        found_any: Collection[str] = None,
+    ):
         self.required = required
         self.found = found
+        # The following fields are used when an instrumentation requires any of a set of dependencies rather than all.
+        self.required_any = required_any
+        self.found_any = found_any
 
     def __str__(self):
+        if not self.required and (self.required_any or self.found_any):
+            return f'DependencyConflict: requested any of the following: "{self.required_any}" but found: "{self.found_any}"'
         return f'DependencyConflict: requested: "{self.required}" but found: "{self.found}"'
 
 
@@ -49,8 +80,39 @@ class DependencyConflictError(Exception):
         return str(self.conflict)
 
 
+def get_dist_dependency_conflicts(
+    dist: Distribution,
+) -> DependencyConflict | None:
+    instrumentation_deps = []
+    instrumentation_any_deps = []
+    extra = "extra"
+    instruments = "instruments"
+    instruments_marker = {extra: instruments}
+    instruments_any = "instruments-any"
+    instruments_any_marker = {extra: instruments_any}
+    if dist.requires:
+        for dep in dist.requires:
+            if extra not in dep:
+                continue
+            if instruments not in dep and instruments_any not in dep:
+                continue
+
+            req = Requirement(dep)
+            if req.marker.evaluate(instruments_marker):  # type: ignore
+                instrumentation_deps.append(req)  # type: ignore
+            if req.marker.evaluate(instruments_any_marker):  # type: ignore
+                instrumentation_any_deps.append(req)  # type: ignore
+    return get_dependency_conflicts(
+        instrumentation_deps, instrumentation_any_deps
+    )  # type: ignore
+
+
 def get_dependency_conflicts(
-    deps: Collection[str | Requirement],
+    deps: Collection[
+        str | Requirement
+    ],  # Dependencies all of which are required
+    deps_any: Collection[str | Requirement]
+    | None = None,  # Dependencies any of which are required
 ) -> DependencyConflict | None:
     for dep in deps:
         if isinstance(dep, Requirement):
@@ -73,4 +135,53 @@ def get_dependency_conflicts(
 
         if not req.specifier.contains(dist_version):
             return DependencyConflict(dep, f"{req.name} {dist_version}")
+
+    # If all the dependencies in "instruments" are present, check "instruments-any" for conflicts.
+    if deps_any:
+        return _get_dependency_conflicts_any(deps_any)
+    return None
+
+
+# This is a helper functions designed to ease reading and meet linting requirements.
+def _get_dependency_conflicts_any(
+    deps_any: Collection[str | Requirement],
+) -> DependencyConflict | None:
+    if not deps_any:
+        return None
+    is_dependency_conflict = True
+    required_any: Collection[str] = []
+    found_any: Collection[str] = []
+    for dep in deps_any:
+        if isinstance(dep, Requirement):
+            req = dep
+        else:
+            try:
+                req = Requirement(dep)
+            except InvalidRequirement as exc:
+                logger.warning(
+                    'error parsing dependency, reporting as a conflict: "%s" - %s',
+                    dep,
+                    exc,
+                )
+                return DependencyConflict(dep)
+
+        try:
+            dist_version = version(req.name)
+        except PackageNotFoundError:
+            required_any.append(str(dep))
+            continue
+
+        if req.specifier.contains(dist_version):
+            # Since only one of the instrumentation_any dependencies is required, there is no dependency conflict.
+            is_dependency_conflict = False
+            break
+        # If the version does not match, add it to the list of unfulfilled requirement options.
+        required_any.append(str(dep))
+        found_any.append(f"{req.name} {dist_version}")
+
+    if is_dependency_conflict:
+        return DependencyConflict(
+            required_any=required_any,
+            found_any=found_any,
+        )
     return None
diff --git a/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py b/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
index 37af27030..e1d98669f 100644
--- a/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
+++ b/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
@@ -19,7 +19,6 @@ from unittest.mock import Mock, call, patch
 from opentelemetry.instrumentation.auto_instrumentation import _load
 from opentelemetry.instrumentation.dependencies import (
     DependencyConflict,
-    DependencyConflictError,
 )
 from opentelemetry.instrumentation.environment_variables import (
     OTEL_PYTHON_CONFIGURATOR,
@@ -27,6 +26,7 @@ from opentelemetry.instrumentation.environment_variables import (
     OTEL_PYTHON_DISTRO,
 )
 from opentelemetry.instrumentation.version import __version__
+from opentelemetry.util._importlib_metadata import EntryPoint, entry_points
 
 
 class TestLoad(TestCase):
@@ -213,10 +213,13 @@ class TestLoad(TestCase):
         "os.environ",
         {OTEL_PYTHON_DISABLED_INSTRUMENTATIONS: " instr1 , instr3 "},
     )
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch(
         "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
-    def test_load_instrumentors(self, iter_mock):
+    def test_load_instrumentors(self, iter_mock, mock_dep):
         # Mock opentelemetry_pre_instrument entry points
         # pylint: disable=too-many-locals
         pre_ep_mock1 = Mock()
@@ -261,6 +264,8 @@ class TestLoad(TestCase):
             (ep_mock1, ep_mock2, ep_mock3, ep_mock4),
             (post_ep_mock1, post_ep_mock2),
         ]
+        # No dependency conflict
+        mock_dep.return_value = None
         _load._load_instrumentors(distro_mock)
         # All opentelemetry_pre_instrument entry points should be loaded
         pre_mock1.assert_called_once()
@@ -269,8 +274,8 @@ class TestLoad(TestCase):
         # Only non-disabled instrumentations should be loaded
         distro_mock.load_instrumentor.assert_has_calls(
             [
-                call(ep_mock2, raise_exception_on_conflict=True),
-                call(ep_mock4, raise_exception_on_conflict=True),
+                call(ep_mock2, skip_dep_check=True),
+                call(ep_mock4, skip_dep_check=True),
             ]
         )
         self.assertEqual(distro_mock.load_instrumentor.call_count, 2)
@@ -282,56 +287,71 @@ class TestLoad(TestCase):
         "os.environ",
         {OTEL_PYTHON_DISABLED_INSTRUMENTATIONS: " instr1 , instr3 "},
     )
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch("opentelemetry.instrumentation.auto_instrumentation._load._logger")
     @patch(
         "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
-    def test_load_instrumentors_dep_conflict(self, iter_mock, mock_logger):  # pylint: disable=no-self-use
+    def test_load_instrumentors_dep_conflict(
+        self, iter_mock, mock_logger, mock_dep
+    ):  # pylint: disable=no-self-use
         ep_mock1 = Mock()
-        ep_mock1.name = "instr1"
+        ep_mock1.name = "instr1"  # disabled
 
         ep_mock2 = Mock()
         ep_mock2.name = "instr2"
 
         ep_mock3 = Mock()
-        ep_mock3.name = "instr3"
+        ep_mock3.name = "instr3"  # disabled
 
         ep_mock4 = Mock()
-        ep_mock4.name = "instr4"
+        ep_mock4.name = "instr4"  # dependency conflict
 
         dependency_conflict = DependencyConflict("1.2.3", None)
 
         distro_mock = Mock()
-        distro_mock.load_instrumentor.side_effect = [
-            None,
-            DependencyConflictError(dependency_conflict),
-        ]
 
-        # If a dependency conflict is raised, that instrumentation should not be loaded, but others still should.
-        # In this case, ep_mock4 will fail to load and ep_mock2 will succeed. (ep_mock1 and ep_mock3 are disabled)
         iter_mock.return_value = (ep_mock1, ep_mock2, ep_mock3, ep_mock4)
+        print((ep_mock1, ep_mock2, ep_mock3, ep_mock4))
+        # If a dependency conflict is raised, that instrumentation should not be loaded, but others still should.
+        # In this case, ep_mock4 will not be loaded and ep_mock2 will succeed. (ep_mock1 and ep_mock3 are disabled)
+        mock_dep.side_effect = [None, dependency_conflict]
         _load._load_instrumentors(distro_mock)
         distro_mock.load_instrumentor.assert_has_calls(
             [
-                call(ep_mock2, raise_exception_on_conflict=True),
-                call(ep_mock4, raise_exception_on_conflict=True),
+                call(ep_mock2, skip_dep_check=True),
             ]
         )
-        assert distro_mock.load_instrumentor.call_count == 2
+        distro_mock.load_instrumentor.assert_called_once()
         mock_logger.debug.assert_has_calls(
             [
+                call(
+                    "Instrumentation skipped for library %s",
+                    ep_mock1.name,
+                ),
+                call("Instrumented %s", ep_mock2.name),
+                call(
+                    "Instrumentation skipped for library %s",
+                    ep_mock3.name,
+                ),
                 self._instrumentation_failed_to_load_call(
-                    ep_mock4.name, dependency_conflict
-                )
+                    ep_mock4.name,
+                    dependency_conflict,
+                ),
             ]
         )
 
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch("opentelemetry.instrumentation.auto_instrumentation._load._logger")
     @patch(
         "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_instrumentors_import_error_does_not_stop_everything(
-        self, iter_mock, mock_logger
+        self, iter_mock, mock_logger, mock_dep
     ):
         ep_mock1 = Mock(name="instr1")
         ep_mock2 = Mock(name="instr2")
@@ -345,13 +365,14 @@ class TestLoad(TestCase):
             (ep_mock1, ep_mock2),
             (),
         ]
+        mock_dep.return_value = None
 
         _load._load_instrumentors(distro_mock)
 
         distro_mock.load_instrumentor.assert_has_calls(
             [
-                call(ep_mock1, raise_exception_on_conflict=True),
-                call(ep_mock2, raise_exception_on_conflict=True),
+                call(ep_mock1, skip_dep_check=True),
+                call(ep_mock2, skip_dep_check=True),
             ]
         )
         self.assertEqual(distro_mock.load_instrumentor.call_count, 2)
@@ -362,10 +383,13 @@ class TestLoad(TestCase):
 
         mock_logger.debug.assert_any_call("Instrumented %s", ep_mock2.name)
 
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch(
         "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
-    def test_load_instrumentors_raises_exception(self, iter_mock):
+    def test_load_instrumentors_raises_exception(self, iter_mock, mock_dep):
         ep_mock1 = Mock(name="instr1")
         ep_mock2 = Mock(name="instr2")
 
@@ -378,23 +402,27 @@ class TestLoad(TestCase):
             (ep_mock1, ep_mock2),
             (),
         ]
+        mock_dep.return_value = None
 
         with self.assertRaises(ValueError):
             _load._load_instrumentors(distro_mock)
 
         distro_mock.load_instrumentor.assert_has_calls(
             [
-                call(ep_mock1, raise_exception_on_conflict=True),
+                call(ep_mock1, skip_dep_check=True),
             ]
         )
         self.assertEqual(distro_mock.load_instrumentor.call_count, 1)
 
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
     @patch("opentelemetry.instrumentation.auto_instrumentation._load._logger")
     @patch(
         "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_instrumentors_module_not_found_error(
-        self, iter_mock, mock_logger
+        self, iter_mock, mock_logger, mock_dep
     ):
         ep_mock1 = Mock()
         ep_mock1.name = "instr1"
@@ -404,6 +432,8 @@ class TestLoad(TestCase):
 
         distro_mock = Mock()
 
+        mock_dep.return_value = None
+
         distro_mock.load_instrumentor.side_effect = [
             ModuleNotFoundError("No module named 'fake_module'"),
             None,
@@ -415,8 +445,8 @@ class TestLoad(TestCase):
 
         distro_mock.load_instrumentor.assert_has_calls(
             [
-                call(ep_mock1, raise_exception_on_conflict=True),
-                call(ep_mock2, raise_exception_on_conflict=True),
+                call(ep_mock1, skip_dep_check=True),
+                call(ep_mock2, skip_dep_check=True),
             ]
         )
         self.assertEqual(distro_mock.load_instrumentor.call_count, 2)
@@ -434,3 +464,31 @@ class TestLoad(TestCase):
         _load._load_instrumentors(distro_mock)
         # this has no specific assert because it is run for every instrumentation
         self.assertTrue(distro_mock)
+
+    def test_entry_point_dist_finder(self):
+        entry_point_finder = _load._EntryPointDistFinder()
+        self.assertTrue(entry_point_finder._mapping)
+        entry_point = list(
+            entry_points(group="opentelemetry_environment_variables")
+        )[0]
+        self.assertTrue(entry_point)
+        self.assertTrue(entry_point.dist)
+
+        # this will not hit cache
+        entry_point_dist = entry_point_finder.dist_for(entry_point)
+        self.assertTrue(entry_point_dist)
+        # dist are not comparable so we are sure we are not hitting the cache
+        self.assertEqual(entry_point.dist, entry_point_dist)
+
+        # this will hit cache
+        entry_point_without_dist = EntryPoint(
+            name=entry_point.name,
+            group=entry_point.group,
+            value=entry_point.value,
+        )
+        self.assertIsNone(entry_point_without_dist.dist)
+        new_entry_point_dist = entry_point_finder.dist_for(
+            entry_point_without_dist
+        )
+        # dist are not comparable, being truthy is enough
+        self.assertTrue(new_entry_point_dist)
diff --git a/opentelemetry-instrumentation/tests/test_dependencies.py b/opentelemetry-instrumentation/tests/test_dependencies.py
index a06d3923e..91bcbaeed 100644
--- a/opentelemetry-instrumentation/tests/test_dependencies.py
+++ b/opentelemetry-instrumentation/tests/test_dependencies.py
@@ -14,14 +14,21 @@
 
 # pylint: disable=protected-access
 
+from unittest.mock import patch
+
 import pytest
 from packaging.requirements import Requirement
 
 from opentelemetry.instrumentation.dependencies import (
     DependencyConflict,
     get_dependency_conflicts,
+    get_dist_dependency_conflicts,
 )
 from opentelemetry.test.test_base import TestBase
+from opentelemetry.util._importlib_metadata import (
+    Distribution,
+    PackageNotFoundError,
+)
 
 
 class TestDependencyConflicts(TestBase):
@@ -62,3 +69,211 @@ class TestDependencyConflicts(TestBase):
             str(conflict),
             f'DependencyConflict: requested: "pytest == 5000" but found: "pytest {pytest.__version__}"',
         )
+
+    def test_get_dist_dependency_conflicts(self):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                return ['test-pkg ~= 1.0; extra == "instruments"']
+
+        dist = MockDistribution()
+
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertTrue(conflict is not None)
+        self.assertTrue(isinstance(conflict, DependencyConflict))
+        self.assertEqual(
+            str(conflict),
+            'DependencyConflict: requested: "test-pkg~=1.0; extra == "instruments"" but found: "None"',
+        )
+
+    def test_get_dist_dependency_conflicts_requires_none(self):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                # TODO: make another test for returning something with a blank list for both and and or
+                return None
+
+        dist = MockDistribution()
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertTrue(conflict is None)
+
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_get_dist_dependency_conflicts_any(self, version_mock):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                return [
+                    'foo ~= 1.0; extra == "instruments-any"',
+                    'bar ~= 1.0; extra == "instruments-any"',
+                ]
+
+        dist = MockDistribution()
+
+        def version_side_effect(package_name):
+            if package_name == "foo":
+                raise PackageNotFoundError("foo not found")
+            if package_name == "bar":
+                return "1.0.0"
+            raise PackageNotFoundError(f"{package_name} not found")
+
+        version_mock.side_effect = version_side_effect
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertIsNone(conflict)
+
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_get_dist_dependency_conflicts_neither(self, version_mock):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                return [
+                    'foo ~= 1.0; extra == "instruments-any"',
+                    'bar ~= 1.0; extra == "instruments-any"',
+                ]
+
+        dist = MockDistribution()
+        # version_mock.side_effect = lambda x: "1.0.0" if x == "foo" else "2.0.0"
+        # version_mock("foo").return_value = "2.0.0"
+        version_mock.side_effect = PackageNotFoundError("not found")
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertTrue(conflict is not None)
+        self.assertTrue(isinstance(conflict, DependencyConflict))
+        self.assertEqual(
+            str(conflict),
+            '''DependencyConflict: requested any of the following: "['foo~=1.0; extra == "instruments-any"', 'bar~=1.0; extra == "instruments-any"']" but found: "[]"''',
+        )
+
+    # Tests when both "and" and "either" dependencies are specified and both pass.
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_get_dist_dependency_conflicts_any_and(self, version_mock):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                # This indicates the instrumentation requires (foo and (bar or baz)))
+                return [
+                    'foo ~= 1.0; extra == "instruments"',
+                    'bar ~= 2.0; extra == "instruments-any"',
+                    'baz ~= 3.0; extra == "instruments-any"',
+                ]
+
+        dist = MockDistribution()
+
+        def version_side_effect(package_name):
+            if package_name == "foo":
+                return "1.2.0"
+            if package_name == "bar":
+                raise PackageNotFoundError("bar not found")
+            if package_name == "baz":
+                return "3.7.0"
+            raise PackageNotFoundError(f"{package_name} not found")
+
+        version_mock.side_effect = version_side_effect
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertIsNone(conflict)
+
+    # Tests when both "and" and "either" dependencies are specified but the "and" dependencies fail to resolve.
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_get_dist_dependency_conflicts_any_and_failed(self, version_mock):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                # This indicates the instrumentation requires (foo and (bar or baz)))
+                return [
+                    'foo ~= 1.0; extra == "instruments"',
+                    'bar ~= 2.0; extra == "instruments-any"',
+                    'baz ~= 3.0; extra == "instruments-any"',
+                ]
+
+        dist = MockDistribution()
+
+        def version_side_effect(package_name):
+            if package_name == "foo":
+                raise PackageNotFoundError("foo not found")
+            if package_name == "bar":
+                raise PackageNotFoundError("bar not found")
+            if package_name == "baz":
+                return "3.7.0"
+            raise PackageNotFoundError(f"{package_name} not found")
+
+        version_mock.side_effect = version_side_effect
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertTrue(conflict is not None)
+        self.assertTrue(isinstance(conflict, DependencyConflict))
+        self.assertEqual(
+            str(conflict),
+            'DependencyConflict: requested: "foo~=1.0; extra == "instruments"" but found: "None"',
+        )
+
+    # Tests when both "and" and "either" dependencies are specified but the "either" dependencies fail to resolve.
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_get_dist_dependency_conflicts_and_any_failed(self, version_mock):
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
+
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                # This indicates the instrumentation requires (foo and (bar or baz)))
+                return [
+                    'foo ~= 1.0; extra == "instruments"',
+                    'bar ~= 2.0; extra == "instruments-any"',
+                    'baz ~= 3.0; extra == "instruments-any"',
+                ]
+
+        dist = MockDistribution()
+
+        def version_side_effect(package_name):
+            if package_name == "foo":
+                return "1.7.0"
+            if package_name == "bar":
+                raise PackageNotFoundError("bar not found")
+            if package_name == "baz":
+                raise PackageNotFoundError("baz not found")
+            raise PackageNotFoundError(f"{package_name} not found")
+
+        version_mock.side_effect = version_side_effect
+        conflict = get_dist_dependency_conflicts(dist)
+        self.assertTrue(conflict is not None)
+        self.assertTrue(isinstance(conflict, DependencyConflict))
+        self.assertEqual(
+            str(conflict),
+            '''DependencyConflict: requested any of the following: "['bar~=2.0; extra == "instruments-any"', 'baz~=3.0; extra == "instruments-any"']" but found: "[]"''',
+        )
diff --git a/pyproject.toml b/pyproject.toml
index 988fa6831..23b171953 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -37,12 +37,14 @@ dependencies = [
   "opentelemetry-instrumentation-httpx[instruments]",
   "opentelemetry-instrumentation-jinja2[instruments]",
   "opentelemetry-instrumentation-kafka-python[instruments]",
+  "opentelemetry-instrumentation-kafka-python[instruments-any]",
   "opentelemetry-instrumentation-logging",
   "opentelemetry-instrumentation-mysql[instruments]",
   "opentelemetry-instrumentation-mysqlclient[instruments]",
   "opentelemetry-instrumentation-pika[instruments]",
   "opentelemetry-instrumentation-psycopg[instruments]",
   "opentelemetry-instrumentation-psycopg2[instruments]",
+  "opentelemetry-instrumentation-psycopg2[instruments-any]",
   "opentelemetry-instrumentation-pymemcache[instruments]",
   "opentelemetry-instrumentation-pymongo[instruments]",
   "opentelemetry-instrumentation-pymysql[instruments]",
diff --git a/scripts/generate_instrumentation_bootstrap.py b/scripts/generate_instrumentation_bootstrap.py
index c8bc0f936..3299a0529 100755
--- a/scripts/generate_instrumentation_bootstrap.py
+++ b/scripts/generate_instrumentation_bootstrap.py
@@ -84,7 +84,7 @@ def main():
         pkg_name = pkg.get("name")
         if pkg_name in packages_to_exclude:
             continue
-        if not pkg["instruments"]:
+        if not pkg["instruments"] and not pkg["instruments-any"]:
             default_instrumentations.elts.append(ast.Str(pkg["requirement"]))
         for target_pkg in pkg["instruments"]:
             libraries.elts.append(
@@ -93,6 +93,14 @@ def main():
                     values=[ast.Str(target_pkg), ast.Str(pkg["requirement"])],
                 )
             )
+        # instruments-any is an optional field that can be used instead of or in addition to _instruments. While _instruments is a list of dependencies, all of which are expected by the instrumentation, instruments-any is a list any of which but not all are expected.
+        for target_pkg in pkg["instruments-any"]:
+            libraries.elts.append(
+                ast.Dict(
+                    keys=[ast.Str("library"), ast.Str("instrumentation")],
+                    values=[ast.Str(target_pkg), ast.Str(pkg["requirement"])],
+                )
+            )
 
     tree = ast.parse(_source_tmpl)
     tree.body[0].value = libraries
diff --git a/scripts/generate_instrumentation_readme.py b/scripts/generate_instrumentation_readme.py
index b4a712cc8..0148480ff 100755
--- a/scripts/generate_instrumentation_readme.py
+++ b/scripts/generate_instrumentation_readme.py
@@ -58,11 +58,16 @@ def main(base_instrumentation_path):
         with open(version_filename, encoding="utf-8") as fh:
             exec(fh.read(), pkg_info)
 
-        instruments = pkg_info["_instruments"]
+        instruments_and = pkg_info.get("_instruments", ())
+        # _instruments_any is an optional field that can be used instead of or in addition to _instruments. While _instruments is a list of dependencies, all of which are expected by the instrumentation, _instruments_any is a list any of which but not all are expected.
+        instruments_any = pkg_info.get("_instruments_any", ())
         supports_metrics = pkg_info.get("_supports_metrics")
         semconv_status = pkg_info.get("_semconv_status")
-        if not instruments:
-            instruments = (name,)
+        instruments_all = ()
+        if not instruments_and and not instruments_any:
+            instruments_all = (name,)
+        else:
+            instruments_all = tuple(instruments_and + instruments_any)
 
         if not semconv_status:
             semconv_status = "development"
@@ -70,7 +75,7 @@ def main(base_instrumentation_path):
         metric_column = "Yes" if supports_metrics else "No"
 
         table.append(
-            f"| [{instrumentation}](./{instrumentation}) | {','.join(instruments)} | {metric_column} | {semconv_status}"
+            f"| [{instrumentation}](./{instrumentation}) | {','.join(instruments_all)} | {metric_column} | {semconv_status}"
         )
 
     with open(
diff --git a/scripts/otel_packaging.py b/scripts/otel_packaging.py
index 12e424cf2..a542b9c06 100644
--- a/scripts/otel_packaging.py
+++ b/scripts/otel_packaging.py
@@ -60,12 +60,17 @@ def get_instrumentation_packages(
         with open(pyproject_toml_path, "rb") as file:
             pyproject_toml = tomli.load(file)
 
+        optional_dependencies = pyproject_toml["project"][
+            "optional-dependencies"
+        ]
+        instruments = optional_dependencies.get("instruments", [])
+        # instruments-any is an optional field that can be used instead of or in addition to instruments. While instruments is a list of dependencies, all of which are expected by the instrumentation, instruments-any is a list any of which but not all are expected.
+        instruments_any = optional_dependencies.get("instruments-any", [])
         instrumentation = {
             "name": pyproject_toml["project"]["name"],
             "version": version.strip(),
-            "instruments": pyproject_toml["project"]["optional-dependencies"][
-                "instruments"
-            ],
+            "instruments": instruments,
+            "instruments-any": instruments_any,
         }
         if instrumentation["name"] in independent_packages:
             specifier = independent_packages[instrumentation["name"]]
diff --git a/uv.lock b/uv.lock
index c4210acc9..4df9f60ec 100644
--- a/uv.lock
+++ b/uv.lock
@@ -2872,20 +2872,20 @@ dependencies = [
 ]
 
 [package.optional-dependencies]
-instruments = [
+instruments-any = [
     { name = "kafka-python" },
     { name = "kafka-python-ng" },
 ]
 
 [package.metadata]
 requires-dist = [
-    { name = "kafka-python", marker = "extra == 'instruments'", specifier = ">=2.0,<3.0" },
-    { name = "kafka-python-ng", marker = "extra == 'instruments'", specifier = ">=2.0,<3.0" },
+    { name = "kafka-python", marker = "extra == 'instruments-any'", specifier = ">=2.0,<3.0" },
+    { name = "kafka-python-ng", marker = "extra == 'instruments-any'", specifier = ">=2.0,<3.0" },
     { name = "opentelemetry-api", git = "https://github.com/open-telemetry/opentelemetry-python?subdirectory=opentelemetry-api&branch=main" },
     { name = "opentelemetry-instrumentation", editable = "opentelemetry-instrumentation" },
     { name = "opentelemetry-semantic-conventions", git = "https://github.com/open-telemetry/opentelemetry-python?subdirectory=opentelemetry-semantic-conventions&branch=main" },
 ]
-provides-extras = ["instruments"]
+provides-extras = ["instruments", "instruments-any"]
 
 [[package]]
 name = "opentelemetry-instrumentation-logging"
@@ -3029,7 +3029,7 @@ dependencies = [
 ]
 
 [package.optional-dependencies]
-instruments = [
+instruments-any = [
     { name = "psycopg2" },
     { name = "psycopg2-binary" },
 ]
@@ -3039,10 +3039,10 @@ requires-dist = [
     { name = "opentelemetry-api", git = "https://github.com/open-telemetry/opentelemetry-python?subdirectory=opentelemetry-api&branch=main" },
     { name = "opentelemetry-instrumentation", editable = "opentelemetry-instrumentation" },
     { name = "opentelemetry-instrumentation-dbapi", editable = "instrumentation/opentelemetry-instrumentation-dbapi" },
-    { name = "psycopg2", marker = "extra == 'instruments'", specifier = ">=2.7.3.1" },
-    { name = "psycopg2-binary", marker = "extra == 'instruments'", specifier = ">=2.7.3.1" },
+    { name = "psycopg2", marker = "extra == 'instruments-any'", specifier = ">=2.7.3.1" },
+    { name = "psycopg2-binary", marker = "extra == 'instruments-any'", specifier = ">=2.7.3.1" },
 ]
-provides-extras = ["instruments"]
+provides-extras = ["instruments", "instruments-any"]
 
 [[package]]
 name = "opentelemetry-instrumentation-pymemcache"
@@ -3548,14 +3548,14 @@ dependencies = [
     { name = "opentelemetry-instrumentation-grpc", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-httpx", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-jinja2", extra = ["instruments"] },
-    { name = "opentelemetry-instrumentation-kafka-python", extra = ["instruments"] },
+    { name = "opentelemetry-instrumentation-kafka-python", extra = ["instruments-any"] },
     { name = "opentelemetry-instrumentation-logging" },
     { name = "opentelemetry-instrumentation-mysql", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-mysqlclient", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-openai-v2", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-pika", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-psycopg", extra = ["instruments"] },
-    { name = "opentelemetry-instrumentation-psycopg2", extra = ["instruments"] },
+    { name = "opentelemetry-instrumentation-psycopg2", extra = ["instruments-any"] },
     { name = "opentelemetry-instrumentation-pymemcache", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-pymongo", extra = ["instruments"] },
     { name = "opentelemetry-instrumentation-pymysql", extra = ["instruments"] },
@@ -3613,6 +3613,7 @@ requires-dist = [
     { name = "opentelemetry-instrumentation-httpx", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-httpx" },
     { name = "opentelemetry-instrumentation-jinja2", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-jinja2" },
     { name = "opentelemetry-instrumentation-kafka-python", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-kafka-python" },
+    { name = "opentelemetry-instrumentation-kafka-python", extras = ["instruments-any"], editable = "instrumentation/opentelemetry-instrumentation-kafka-python" },
     { name = "opentelemetry-instrumentation-logging", editable = "instrumentation/opentelemetry-instrumentation-logging" },
     { name = "opentelemetry-instrumentation-mysql", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-mysql" },
     { name = "opentelemetry-instrumentation-mysqlclient", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-mysqlclient" },
@@ -3620,6 +3621,7 @@ requires-dist = [
     { name = "opentelemetry-instrumentation-pika", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-pika" },
     { name = "opentelemetry-instrumentation-psycopg", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-psycopg" },
     { name = "opentelemetry-instrumentation-psycopg2", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-psycopg2" },
+    { name = "opentelemetry-instrumentation-psycopg2", extras = ["instruments-any"], editable = "instrumentation/opentelemetry-instrumentation-psycopg2" },
     { name = "opentelemetry-instrumentation-pymemcache", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-pymemcache" },
     { name = "opentelemetry-instrumentation-pymongo", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-pymongo" },
     { name = "opentelemetry-instrumentation-pymysql", extras = ["instruments"], editable = "instrumentation/opentelemetry-instrumentation-pymysql" },