diff --git a/CHANGELOG.md b/CHANGELOG.md
index feb5441ef..d7fa3863b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#739](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/739))
 - Add support for Python 3.10
   ([#742](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/742))
+- `opentelemetry-instrumentation` Add `setuptools` to `install_requires`
+  ([#781](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/781))
 
 ### Fixed
 
diff --git a/opentelemetry-instrumentation/setup.cfg b/opentelemetry-instrumentation/setup.cfg
index 4c61cf0a6..57f7936b4 100644
--- a/opentelemetry-instrumentation/setup.cfg
+++ b/opentelemetry-instrumentation/setup.cfg
@@ -43,6 +43,7 @@ zip_safe = False
 include_package_data = True
 install_requires =
     opentelemetry-api ~= 1.4
+    setuptools >= 16.0
     wrapt >= 1.0.0, < 2.0.0
 
 [options.packages.find]