diff --git a/CHANGELOG.md b/CHANGELOG.md
index 89495abe7..fb92d5650 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -16,6 +16,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#2300](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2300))
 - Rename AwsLambdaInstrumentor span attributes `faas.id` to `cloud.resource_id`, `faas.execution` to `faas.invocation_id`
   ([#2372](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2372))
+- Drop support for instrumenting elasticsearch client < 6`
+  ([#2422](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2422))
 
 ### Added
 
diff --git a/docs-requirements.txt b/docs-requirements.txt
index aff449fcf..72f447290 100644
--- a/docs-requirements.txt
+++ b/docs-requirements.txt
@@ -28,7 +28,7 @@ boto3~=1.0
 cassandra-driver~=3.25
 celery>=4.0
 confluent-kafka>= 1.8.2,<= 2.3.0
-elasticsearch>=2.0,<9.0
+elasticsearch>=6.0,<9.0
 flask~=2.0
 falcon~=2.0
 grpcio~=1.27
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
index 659366181..f5ba221b7 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
@@ -32,7 +32,7 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = [
-  "elasticsearch >= 2.0",
+  "elasticsearch >= 6.0",
 ]
 
 [project.entry-points.opentelemetry_instrumentor]
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
deleted file mode 100644
index 216d1c0b0..000000000
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
+++ /dev/null
@@ -1,22 +0,0 @@
-asgiref==3.7.2
-attrs==23.2.0
-Deprecated==1.2.14
-elasticsearch==2.4.1
-elasticsearch-dsl==2.2.0
-importlib-metadata==6.11.0
-iniconfig==2.0.0
-packaging==23.2
-pluggy==1.4.0
-py==1.11.0
-py-cpuinfo==9.0.0
-pytest==7.1.3
-pytest-benchmark==4.0.0
-python-dateutil==2.8.2
-six==1.16.0
-tomli==2.0.1
-typing_extensions==4.10.0
-urllib3==1.26.18
-wrapt==1.16.0
-zipp==3.17.0
--e opentelemetry-instrumentation
--e instrumentation/opentelemetry-instrumentation-elasticsearch
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
deleted file mode 100644
index 2c51c8750..000000000
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
+++ /dev/null
@@ -1,22 +0,0 @@
-asgiref==3.7.2
-attrs==23.2.0
-Deprecated==1.2.14
-elasticsearch==5.5.3
-elasticsearch-dsl==5.4.0
-importlib-metadata==6.11.0
-iniconfig==2.0.0
-packaging==23.2
-pluggy==1.4.0
-py==1.11.0
-py-cpuinfo==9.0.0
-pytest==7.1.3
-pytest-benchmark==4.0.0
-python-dateutil==2.8.2
-six==1.16.0
-tomli==2.0.1
-typing_extensions==4.10.0
-urllib3==2.2.1
-wrapt==1.16.0
-zipp==3.17.0
--e opentelemetry-instrumentation
--e instrumentation/opentelemetry-instrumentation-elasticsearch
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-6.txt
similarity index 100%
rename from instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
rename to instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-6.txt
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/helpers_es2.py b/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/helpers_es2.py
deleted file mode 100644
index 008a95d67..000000000
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/helpers_es2.py
+++ /dev/null
@@ -1,33 +0,0 @@
-from elasticsearch_dsl import (  # pylint: disable=no-name-in-module
-    DocType,
-    String,
-)
-
-
-class Article(DocType):
-    title = String(analyzer="snowball", fields={"raw": String()})
-    body = String(analyzer="snowball")
-
-    class Meta:
-        index = "test-index"
-
-
-dsl_create_statement = {
-    "mappings": {
-        "article": {
-            "properties": {
-                "title": {
-                    "analyzer": "snowball",
-                    "fields": {"raw": {"type": "string"}},
-                    "type": "string",
-                },
-                "body": {"analyzer": "snowball", "type": "string"},
-            }
-        }
-    },
-    "settings": {"analysis": {}},
-}
-dsl_index_result = (1, {}, '{"created": true}')
-dsl_index_span_name = "Elasticsearch/test-index/article/2"
-dsl_index_url = "/test-index/article/2"
-dsl_search_method = "GET"
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/helpers_es5.py b/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/helpers_es5.py
deleted file mode 100644
index cf32d9886..000000000
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/helpers_es5.py
+++ /dev/null
@@ -1,33 +0,0 @@
-from elasticsearch_dsl import (  # pylint: disable=no-name-in-module
-    DocType,
-    Keyword,
-    Text,
-)
-
-
-class Article(DocType):
-    title = Text(analyzer="snowball", fields={"raw": Keyword()})
-    body = Text(analyzer="snowball")
-
-    class Meta:
-        index = "test-index"
-
-
-dsl_create_statement = {
-    "mappings": {
-        "article": {
-            "properties": {
-                "title": {
-                    "analyzer": "snowball",
-                    "fields": {"raw": {"type": "keyword"}},
-                    "type": "text",
-                },
-                "body": {"analyzer": "snowball", "type": "text"},
-            }
-        }
-    },
-}
-dsl_index_result = (1, {}, '{"created": true}')
-dsl_index_span_name = "Elasticsearch/test-index/article/2"
-dsl_index_url = "/test-index/article/2"
-dsl_search_method = "GET"
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/test_elasticsearch.py b/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/test_elasticsearch.py
index 6008108d7..5d1c85f77 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/test_elasticsearch.py
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/tests/test_elasticsearch.py
@@ -44,10 +44,6 @@ elif major_version == 7:
     from . import helpers_es7 as helpers  # pylint: disable=no-name-in-module
 elif major_version == 6:
     from . import helpers_es6 as helpers  # pylint: disable=no-name-in-module
-elif major_version == 5:
-    from . import helpers_es5 as helpers  # pylint: disable=no-name-in-module
-else:
-    from . import helpers_es2 as helpers  # pylint: disable=no-name-in-module
 
 Article = helpers.Article
 
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index 455d08e41..9eebd5bb3 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -73,7 +73,7 @@ libraries = [
         "instrumentation": "opentelemetry-instrumentation-django==0.46b0.dev",
     },
     {
-        "library": "elasticsearch >= 2.0",
+        "library": "elasticsearch >= 6.0",
         "instrumentation": "opentelemetry-instrumentation-elasticsearch==0.46b0.dev",
     },
     {
diff --git a/tox.ini b/tox.ini
index 3583b7319..bee544cb7 100644
--- a/tox.ini
+++ b/tox.ini
@@ -78,13 +78,9 @@ envlist =
     ; FIXME: Elasticsearch >=7 causes CI workflow tests to hang, see open-telemetry/opentelemetry-python-contrib#620
     ; The numbers at the end of the environment names
     ; below mean these dependencies are being used:
-    ; 0: elasticsearch-dsl>=2.0,<3.0 elasticsearch>=2.0,<3.0
-    ; 1: elasticsearch-dsl>=5.0,<6.0 elasticsearch>=5.0,<6.0
-    ; 2: elasticsearch-dsl>=6.0,<7.0 elasticsearch>=6.0,<7.0
-    py3{8,9,10,11}-test-instrumentation-elasticsearch-{0,2}
-    pypy3-test-instrumentation-elasticsearch-{0,2}
-    py3{8,9}-test-instrumentation-elasticsearch-1
-    pypy3-test-instrumentation-elasticsearch-1
+    ; 6: elasticsearch-dsl>=6.0,<7.0 elasticsearch>=6.0,<7.0
+    py3{8,9,10,11}-test-instrumentation-elasticsearch-6
+    pypy3-test-instrumentation-elasticsearch-6
 
     ; opentelemetry-instrumentation-falcon
     ; py310 does not work with falcon 1
@@ -452,9 +448,7 @@ commands_pre =
   sqlalchemy-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
   sqlalchemy-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
 
-  elasticsearch-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
-  elasticsearch-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
-  elasticsearch-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
+  elasticsearch-6: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-6.txt
 
   asyncio: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
 
@@ -617,7 +611,7 @@ commands_pre =
   # prerequisite: follow the instructions here https://github.com/PyMySQL/mysqlclient#install
   # for your OS to install the required dependencies
   pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
-  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-6.txt
   pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
   pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
   pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt