diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py
index 028804f59..f8a72931f 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py
@@ -26,7 +26,7 @@ import grpc
 
 from opentelemetry import metrics, propagators, trace
 from opentelemetry.sdk.metrics.export.controller import PushController
-from opentelemetry.trace.status import Status, StatusCanonicalCode
+from opentelemetry.trace.status import Status, StatusCode
 
 from . import grpcext
 from ._utilities import RpcInfo, TimedMetricRecorder
@@ -169,9 +169,9 @@ class OpenTelemetryClientInterceptor(
 
                 try:
                     result = invoker(request, metadata)
-                except grpc.RpcError as exc:
+                except grpc.RpcError:
                     guarded_span.generated_span.set_status(
-                        Status(StatusCanonicalCode(exc.code().value[0]))
+                        Status(StatusCode.ERROR)
                     )
                     raise
 
@@ -224,10 +224,8 @@ class OpenTelemetryClientInterceptor(
                                 response.ByteSize(), client_info.full_method
                             )
                         yield response
-                except grpc.RpcError as exc:
-                    span.set_status(
-                        Status(StatusCanonicalCode(exc.code().value[0]))
-                    )
+                except grpc.RpcError:
+                    span.set_status(Status(StatusCode.ERROR))
                     raise
 
     def intercept_stream(
@@ -264,9 +262,9 @@ class OpenTelemetryClientInterceptor(
 
                 try:
                     result = invoker(request_or_iterator, metadata)
-                except grpc.RpcError as exc:
+                except grpc.RpcError:
                     guarded_span.generated_span.set_status(
-                        Status(StatusCanonicalCode(exc.code().value[0]))
+                        Status(StatusCode.ERROR)
                     )
                     raise
 
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
index 3ed40c141..f351c6fdd 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
@@ -220,9 +220,8 @@ class TestClientProto(TestBase):
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 1)
         span = spans[0]
-        self.assertEqual(
-            span.status.canonical_code.value,
-            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        self.assertIs(
+            span.status.status_code, trace.status.StatusCode.ERROR,
         )
 
     def test_error_stream_unary(self):
@@ -233,9 +232,8 @@ class TestClientProto(TestBase):
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 1)
         span = spans[0]
-        self.assertEqual(
-            span.status.canonical_code.value,
-            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        self.assertIs(
+            span.status.status_code, trace.status.StatusCode.ERROR,
         )
 
     def test_error_unary_stream(self):
@@ -247,9 +245,8 @@ class TestClientProto(TestBase):
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 1)
         span = spans[0]
-        self.assertEqual(
-            span.status.canonical_code.value,
-            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        self.assertIs(
+            span.status.status_code, trace.status.StatusCode.ERROR,
         )
 
     def test_error_stream_stream(self):
@@ -263,9 +260,8 @@ class TestClientProto(TestBase):
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 1)
         span = spans[0]
-        self.assertEqual(
-            span.status.canonical_code.value,
-            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        self.assertIs(
+            span.status.status_code, trace.status.StatusCode.ERROR,
         )