diff --git a/pkg/api/accesscontrol.go b/pkg/api/accesscontrol.go
index 7555a413722..e6df844a3af 100644
--- a/pkg/api/accesscontrol.go
+++ b/pkg/api/accesscontrol.go
@@ -2,6 +2,7 @@ package api
 
 import (
 	"github.com/grafana/grafana/pkg/models"
+	"github.com/grafana/grafana/pkg/plugins"
 	ac "github.com/grafana/grafana/pkg/services/accesscontrol"
 	"github.com/grafana/grafana/pkg/services/dashboards"
 	"github.com/grafana/grafana/pkg/services/datasources"
@@ -36,6 +37,11 @@ var (
 // grants to organization roles ("Viewer", "Editor", "Admin") or "Grafana Admin"
 // that HTTPServer needs
 func (hs *HTTPServer) declareFixedRoles() error {
+	// Declare plugins roles
+	if err := plugins.DeclareRBACRoles(hs.AccessControl); err != nil {
+		return err
+	}
+
 	provisioningWriterRole := ac.RoleRegistration{
 		Role: ac.RoleDTO{
 			Name:        "fixed:provisioning:writer",
diff --git a/pkg/api/api.go b/pkg/api/api.go
index 60ea3ca91f5..b6385a34ecc 100644
--- a/pkg/api/api.go
+++ b/pkg/api/api.go
@@ -9,6 +9,7 @@ import (
 	"github.com/grafana/grafana/pkg/infra/log"
 	"github.com/grafana/grafana/pkg/middleware"
 	"github.com/grafana/grafana/pkg/models"
+	"github.com/grafana/grafana/pkg/plugins"
 	ac "github.com/grafana/grafana/pkg/services/accesscontrol"
 	"github.com/grafana/grafana/pkg/services/dashboards"
 	"github.com/grafana/grafana/pkg/services/datasources"
@@ -88,8 +89,10 @@ func (hs *HTTPServer) registerRoutes() {
 	r.Get("/plugins/:id/", reqSignedIn, hs.Index)
 	r.Get("/plugins/:id/edit", reqSignedIn, hs.Index) // deprecated
 	r.Get("/plugins/:id/page/:page", reqSignedIn, hs.Index)
-	r.Get("/a/:id/*", reqSignedIn, hs.Index) // App Root Page
-	r.Get("/a/:id", reqSignedIn, hs.Index)
+	// App Root Page
+	appPluginIDScope := plugins.ScopeProvider.GetResourceScope(":id")
+	r.Get("/a/:id/*", authorize(reqSignedIn, ac.EvalPermission(plugins.ActionAppAccess, appPluginIDScope)), hs.Index)
+	r.Get("/a/:id", authorize(reqSignedIn, ac.EvalPermission(plugins.ActionAppAccess, appPluginIDScope)), hs.Index)
 
 	r.Get("/d/:uid/:slug", reqSignedIn, redirectFromLegacyPanelEditURL, hs.Index)
 	r.Get("/d/:uid", reqSignedIn, redirectFromLegacyPanelEditURL, hs.Index)
@@ -325,12 +328,13 @@ func (hs *HTTPServer) registerRoutes() {
 			datasourceRoute.Get("/id/:name", authorize(reqSignedIn, ac.EvalPermission(datasources.ActionIDRead, nameScope)), routing.Wrap(hs.GetDataSourceIdByName))
 		})
 
+		pluginIDScope := plugins.ScopeProvider.GetResourceScope(":pluginId")
 		apiRoute.Get("/plugins", routing.Wrap(hs.GetPluginList))
-		apiRoute.Get("/plugins/:pluginId/settings", routing.Wrap(hs.GetPluginSettingByID))
+		apiRoute.Get("/plugins/:pluginId/settings", routing.Wrap(hs.GetPluginSettingByID)) // RBAC check performed in handler for App Plugins
 		apiRoute.Get("/plugins/:pluginId/markdown/:name", routing.Wrap(hs.GetPluginMarkdown))
 		apiRoute.Get("/plugins/:pluginId/health", routing.Wrap(hs.CheckHealth))
-		apiRoute.Any("/plugins/:pluginId/resources", hs.CallResource)
-		apiRoute.Any("/plugins/:pluginId/resources/*", hs.CallResource)
+		apiRoute.Any("/plugins/:pluginId/resources", authorize(reqSignedIn, ac.EvalPermission(plugins.ActionAppAccess, pluginIDScope)), hs.CallResource)
+		apiRoute.Any("/plugins/:pluginId/resources/*", authorize(reqSignedIn, ac.EvalPermission(plugins.ActionAppAccess, pluginIDScope)), hs.CallResource)
 		apiRoute.Get("/plugins/errors", routing.Wrap(hs.GetPluginErrorsList))
 
 		if hs.Cfg.PluginAdminEnabled && !hs.Cfg.PluginAdminExternalManageEnabled {
diff --git a/pkg/api/app_routes.go b/pkg/api/app_routes.go
index c855edde892..03d30848d72 100644
--- a/pkg/api/app_routes.go
+++ b/pkg/api/app_routes.go
@@ -13,6 +13,7 @@ import (
 	"github.com/grafana/grafana/pkg/middleware"
 	"github.com/grafana/grafana/pkg/models"
 	"github.com/grafana/grafana/pkg/plugins"
+	ac "github.com/grafana/grafana/pkg/services/accesscontrol"
 	"github.com/grafana/grafana/pkg/util"
 	"github.com/grafana/grafana/pkg/web"
 )
@@ -42,6 +43,11 @@ func (hs *HTTPServer) initAppPluginRoutes(r *web.Mux) {
 				ReqSignedIn: true,
 			}))
 
+			// Preventing access to plugin routes if the user has no right to access the plugin
+			authorize := ac.Middleware(hs.AccessControl)
+			handlers = append(handlers, authorize(middleware.ReqSignedIn,
+				ac.EvalPermission(plugins.ActionAppAccess, plugins.ScopeProvider.GetResourceScope(plugin.ID))))
+
 			if route.ReqRole != "" {
 				if route.ReqRole == models.ROLE_ADMIN {
 					handlers = append(handlers, middleware.RoleAuth(models.ROLE_ADMIN))
@@ -49,6 +55,7 @@ func (hs *HTTPServer) initAppPluginRoutes(r *web.Mux) {
 					handlers = append(handlers, middleware.RoleAuth(models.ROLE_EDITOR, models.ROLE_ADMIN))
 				}
 			}
+
 			handlers = append(handlers, AppPluginRoute(route, plugin.ID, hs))
 			for _, method := range strings.Split(route.Method, ",") {
 				r.Handle(strings.TrimSpace(method), url, handlers)
diff --git a/pkg/api/index.go b/pkg/api/index.go
index 00c375931c6..9ab27c752c5 100644
--- a/pkg/api/index.go
+++ b/pkg/api/index.go
@@ -76,6 +76,7 @@ func (hs *HTTPServer) getProfileNode(c *models.ReqContext) *dtos.NavLink {
 }
 
 func (hs *HTTPServer) getAppLinks(c *models.ReqContext) ([]*dtos.NavLink, error) {
+	hasAccess := ac.HasAccess(hs.AccessControl, c)
 	enabledPlugins, err := hs.enabledPlugins(c.Req.Context(), c.OrgId)
 	if err != nil {
 		return nil, err
@@ -87,6 +88,11 @@ func (hs *HTTPServer) getAppLinks(c *models.ReqContext) ([]*dtos.NavLink, error)
 			continue
 		}
 
+		if !hasAccess(ac.ReqSignedIn,
+			ac.EvalPermission(plugins.ActionAppAccess, plugins.ScopeProvider.GetResourceScope(plugin.ID))) {
+			continue
+		}
+
 		appLink := &dtos.NavLink{
 			Text:       plugin.Name,
 			Id:         "plugin-page-" + plugin.ID,
diff --git a/pkg/api/plugins.go b/pkg/api/plugins.go
index bed48fa2ebb..ffe3101a016 100644
--- a/pkg/api/plugins.go
+++ b/pkg/api/plugins.go
@@ -119,7 +119,17 @@ func (hs *HTTPServer) GetPluginSettingByID(c *models.ReqContext) response.Respon
 
 	plugin, exists := hs.pluginStore.Plugin(c.Req.Context(), pluginID)
 	if !exists {
-		return response.Error(404, "Plugin not found, no installed plugin with that id", nil)
+		return response.Error(http.StatusNotFound, "Plugin not found, no installed plugin with that id", nil)
+	}
+
+	// In a first iteration, we only have one permission for app plugins.
+	// We will need a different permission to allow users to configure the plugin without needing access to it.
+	if plugin.IsApp() {
+		hasAccess := accesscontrol.HasAccess(hs.AccessControl, c)
+		if !hasAccess(accesscontrol.ReqSignedIn,
+			accesscontrol.EvalPermission(plugins.ActionAppAccess, plugins.ScopeProvider.GetResourceScope(plugin.ID))) {
+			return response.Error(http.StatusForbidden, "Access Denied", nil)
+		}
 	}
 
 	dto := &dtos.PluginSetting{
diff --git a/pkg/plugins/accesscontrol.go b/pkg/plugins/accesscontrol.go
new file mode 100644
index 00000000000..be402538dc8
--- /dev/null
+++ b/pkg/plugins/accesscontrol.go
@@ -0,0 +1,30 @@
+package plugins
+
+import (
+	"github.com/grafana/grafana/pkg/models"
+	ac "github.com/grafana/grafana/pkg/services/accesscontrol"
+)
+
+const (
+	ActionAppAccess = "plugins.app:access"
+)
+
+var (
+	ScopeProvider = ac.NewScopeProvider("plugins")
+)
+
+func DeclareRBACRoles(acService ac.AccessControl) error {
+	AppPluginsReader := ac.RoleRegistration{
+		Role: ac.RoleDTO{
+			Name:        ac.FixedRolePrefix + "plugins.app:reader",
+			DisplayName: "Application Plugins Access",
+			Description: "Access application plugins (still enforcing the organization role)",
+			Group:       "Plugins",
+			Permissions: []ac.Permission{
+				{Action: ActionAppAccess, Scope: ScopeProvider.GetResourceAllScope()},
+			},
+		},
+		Grants: []string{string(models.ROLE_VIEWER)},
+	}
+	return acService.DeclareFixedRoles(AppPluginsReader)
+}
diff --git a/pkg/plugins/manager/manager_integration_test.go b/pkg/plugins/manager/manager_integration_test.go
index 308635bbb89..96c903a05a1 100644
--- a/pkg/plugins/manager/manager_integration_test.go
+++ b/pkg/plugins/manager/manager_integration_test.go
@@ -7,6 +7,11 @@ import (
 	"strings"
 	"testing"
 
+	"github.com/stretchr/testify/assert"
+	"github.com/stretchr/testify/require"
+	"go.opentelemetry.io/otel/trace"
+	"gopkg.in/ini.v1"
+
 	"github.com/grafana/grafana-plugin-sdk-go/backend/httpclient"
 	"github.com/grafana/grafana/pkg/infra/tracing"
 	"github.com/grafana/grafana/pkg/plugins"
@@ -35,12 +40,6 @@ import (
 	"github.com/grafana/grafana/pkg/tsdb/prometheus"
 	"github.com/grafana/grafana/pkg/tsdb/tempo"
 	"github.com/grafana/grafana/pkg/tsdb/testdatasource"
-	"go.opentelemetry.io/otel/trace"
-
-	"github.com/stretchr/testify/assert"
-	"github.com/stretchr/testify/require"
-
-	"gopkg.in/ini.v1"
 )
 
 func TestPluginManager_int_init(t *testing.T) {
diff --git a/pkg/plugins/manager/manager_test.go b/pkg/plugins/manager/manager_test.go
index 22f1c3e233c..d29318cad33 100644
--- a/pkg/plugins/manager/manager_test.go
+++ b/pkg/plugins/manager/manager_test.go
@@ -7,12 +7,11 @@ import (
 	"testing"
 	"time"
 
-	"github.com/grafana/grafana-azure-sdk-go/azsettings"
-	"github.com/grafana/grafana-plugin-sdk-go/backend"
-
 	"github.com/stretchr/testify/assert"
 	"github.com/stretchr/testify/require"
 
+	"github.com/grafana/grafana-azure-sdk-go/azsettings"
+	"github.com/grafana/grafana-plugin-sdk-go/backend"
 	"github.com/grafana/grafana/pkg/infra/log"
 	"github.com/grafana/grafana/pkg/plugins"
 	"github.com/grafana/grafana/pkg/plugins/backendplugin"