diff --git a/core/src/components/item-sliding/item-sliding.tsx b/core/src/components/item-sliding/item-sliding.tsx
index bd20878f97..f6359404ac 100644
--- a/core/src/components/item-sliding/item-sliding.tsx
+++ b/core/src/components/item-sliding/item-sliding.tsx
@@ -3,6 +3,7 @@ import { Component, Element, Event, Host, Method, Prop, State, Watch, h } from '
 
 import { getIonMode } from '../../global/ionic-global';
 import type { Gesture, GestureDetail, Side } from '../../interface';
+import { findClosestIonContent, disableContentScrollY, resetContentScrollY } from '../../utils/content';
 import { isEndSide } from '../../utils/helpers';
 
 const SWIPE_MARGIN = 30;
@@ -43,7 +44,7 @@ export class ItemSliding implements ComponentInterface {
   private rightOptions?: HTMLIonItemOptionsElement;
   private optsDirty = true;
   private gesture?: Gesture;
-  private closestContent: HTMLIonContentElement | null = null;
+  private contentEl: HTMLElement | null = null;
   private initialContentScrollY = true;
 
   @Element() el!: HTMLIonItemSlidingElement;
@@ -68,7 +69,7 @@ export class ItemSliding implements ComponentInterface {
 
   async connectedCallback() {
     this.item = this.el.querySelector('ion-item');
-    this.closestContent = this.el.closest('ion-content');
+    this.contentEl = findClosestIonContent(this.el);
 
     await this.updateOptions();
 
@@ -264,23 +265,6 @@ export class ItemSliding implements ComponentInterface {
     return !!(this.rightOptions || this.leftOptions);
   }
 
-  private disableContentScrollY() {
-    if (this.closestContent === null) {
-      return;
-    }
-
-    this.initialContentScrollY = this.closestContent.scrollY;
-    this.closestContent.scrollY = false;
-  }
-
-  private restoreContentScrollY() {
-    if (this.closestContent === null) {
-      return;
-    }
-
-    this.closestContent.scrollY = this.initialContentScrollY;
-  }
-
   private onStart() {
     /**
      * We need to query for the ion-item
@@ -289,8 +273,10 @@ export class ItemSliding implements ComponentInterface {
      */
     this.item = this.el.querySelector('ion-item');
 
-    // Prevent scrolling during gesture
-    this.disableContentScrollY();
+    const { contentEl } = this;
+    if (contentEl) {
+      this.initialContentScrollY = disableContentScrollY(contentEl);
+    }
 
     openSlidingItem = this.el;
 
@@ -343,8 +329,10 @@ export class ItemSliding implements ComponentInterface {
   }
 
   private onEnd(gesture: GestureDetail) {
-    // Restore ion-content scrollY to initial value when gesture ends
-    this.restoreContentScrollY();
+    const { contentEl, initialContentScrollY } = this;
+    if (contentEl) {
+      resetContentScrollY(contentEl, initialContentScrollY);
+    }
 
     const velocity = gesture.velocityX;
 
diff --git a/core/src/components/item-sliding/test/basic/index.html b/core/src/components/item-sliding/test/basic/index.html
index cebd73b958..a9bed0e0bd 100644
--- a/core/src/components/item-sliding/test/basic/index.html
+++ b/core/src/components/item-sliding/test/basic/index.html
@@ -75,7 +75,7 @@
               </ion-item-options>
             </ion-item-sliding>
 
-            <ion-item-sliding id="item6">
+            <ion-item-sliding id="two-options">
               <ion-item>
                 <ion-label> Two options, one dynamic option and text </ion-label>
               </ion-item>
@@ -89,7 +89,7 @@
                   <ion-icon slot="start" ios="ellipsis-horizontal" md="ellipsis-vertical"></ion-icon>
                   <span class="more-text"></span>
                 </ion-item-option>
-                <ion-item-option color="secondary" onclick="archive('item6')">
+                <ion-item-option color="secondary" onclick="archive('two-options')">
                   <ion-icon slot="start" name="archive"></ion-icon>
                   <span class="archive-text"></span>
                 </ion-item-option>
diff --git a/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts b/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts
new file mode 100644
index 0000000000..33c0511151
--- /dev/null
+++ b/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts
@@ -0,0 +1,35 @@
+import { expect } from '@playwright/test';
+import { test } from '@utils/test/playwright';
+
+test.describe('item-sliding: basic', () => {
+  test('should not scroll when the item-sliding is swiped', async ({ page, browserName }, testInfo) => {
+    test.skip(browserName === 'webkit', 'mouse.wheel is not available in WebKit');
+    test.skip(testInfo.project.metadata.rtl === true, 'This feature does not have RTL-specific behaviors');
+
+    await page.goto(`/src/components/item-sliding/test/basic`);
+
+    const itemSlidingEl = page.locator('#two-options');
+    const scrollEl = page.locator('ion-content .inner-scroll');
+
+    expect(await scrollEl.evaluate((el: HTMLElement) => el.scrollTop)).toEqual(0);
+
+    const box = (await itemSlidingEl.boundingBox())!;
+    const centerX = box.x + box.width / 2;
+    const centerY = box.y + box.height / 2;
+
+    await page.mouse.move(centerX, centerY);
+    await page.mouse.down();
+    await page.mouse.move(centerX - 30, centerY);
+
+    /**
+     * Do not use scrollToBottom() or other scrolling methods
+     * on ion-content as those will update the scroll position.
+     * Setting scrollTop still works even with overflow-y: hidden.
+     * However, simulating a user gesture should not scroll the content.
+     */
+    await page.mouse.wheel(0, 100);
+    await page.waitForChanges();
+
+    expect(await scrollEl.evaluate((el: HTMLElement) => el.scrollTop)).toEqual(0);
+  });
+});
diff --git a/core/src/components/item-sliding/test/scroll-target/index.html b/core/src/components/item-sliding/test/scroll-target/index.html
new file mode 100644
index 0000000000..813e94363e
--- /dev/null
+++ b/core/src/components/item-sliding/test/scroll-target/index.html
@@ -0,0 +1,89 @@
+<!DOCTYPE html>
+<html lang="en" dir="ltr">
+  <head>
+    <meta charset="UTF-8" />
+    <title>Item Sliding - Scroll Target</title>
+    <meta
+      name="viewport"
+      content="width=device-width, initial-scale=1.0, minimum-scale=1.0, maximum-scale=1.0, user-scalable=no"
+    />
+    <link href="../../../../../css/ionic.bundle.css" rel="stylesheet" />
+    <link href="../../../../../scripts/testing/styles.css" rel="stylesheet" />
+    <script src="../../../../../scripts/testing/scripts.js"></script>
+    <script nomodule src="../../../../../dist/ionic/ionic.js"></script>
+    <script type="module" src="../../../../../dist/ionic/ionic.esm.js"></script>
+    <style>
+      .ion-content-scroll-host {
+        width: 100%;
+        height: 100%;
+
+        overflow-y: scroll;
+      }
+    </style>
+  </head>
+  <body>
+    <ion-app>
+      <ion-header>
+        <ion-toolbar>
+          <ion-title>Item Sliding - Scroll Target</ion-title>
+        </ion-toolbar>
+      </ion-header>
+
+      <ion-content class="ion-padding" scroll-y="false">
+        <div class="ion-content-scroll-host">
+          <p>
+            Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur faucibus nulla a nunc tincidunt semper.
+            Nam nibh lorem, pharetra ac ex ac, tempus fringilla est. Aenean tincidunt ipsum pellentesque, consequat
+            libero id, feugiat leo. In vestibulum faucibus velit, non tincidunt erat tincidunt in. Donec a diam sed nisl
+            convallis maximus. Aenean cursus sagittis lorem vitae tristique. Pellentesque pellentesque, quam eget
+            lobortis finibus, lectus lorem maximus purus, quis sagittis tortor sem sed tellus.
+          </p>
+
+          <ion-item-sliding>
+            <ion-item>
+              <ion-label>Item Sliding</ion-label>
+            </ion-item>
+            <ion-item-options side="end" class="show-options">
+              <ion-item-option color="primary">
+                <ion-icon slot="start" ios="ellipsis-horizontal" md="ellipsis-vertical"></ion-icon>
+                <span class="more-text"></span>
+              </ion-item-option>
+            </ion-item-options>
+          </ion-item-sliding>
+
+          <p>
+            Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur faucibus nulla a nunc tincidunt semper.
+            Nam nibh lorem, pharetra ac ex ac, tempus fringilla est. Aenean tincidunt ipsum pellentesque, consequat
+            libero id, feugiat leo. In vestibulum faucibus velit, non tincidunt erat tincidunt in. Donec a diam sed nisl
+            convallis maximus. Aenean cursus sagittis lorem vitae tristique. Pellentesque pellentesque, quam eget
+            lobortis finibus, lectus lorem maximus purus, quis sagittis tortor sem sed tellus.
+          </p>
+
+          <p>
+            Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur faucibus nulla a nunc tincidunt semper.
+            Nam nibh lorem, pharetra ac ex ac, tempus fringilla est. Aenean tincidunt ipsum pellentesque, consequat
+            libero id, feugiat leo. In vestibulum faucibus velit, non tincidunt erat tincidunt in. Donec a diam sed nisl
+            convallis maximus. Aenean cursus sagittis lorem vitae tristique. Pellentesque pellentesque, quam eget
+            lobortis finibus, lectus lorem maximus purus, quis sagittis tortor sem sed tellus.
+          </p>
+
+          <p>
+            Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur faucibus nulla a nunc tincidunt semper.
+            Nam nibh lorem, pharetra ac ex ac, tempus fringilla est. Aenean tincidunt ipsum pellentesque, consequat
+            libero id, feugiat leo. In vestibulum faucibus velit, non tincidunt erat tincidunt in. Donec a diam sed nisl
+            convallis maximus. Aenean cursus sagittis lorem vitae tristique. Pellentesque pellentesque, quam eget
+            lobortis finibus, lectus lorem maximus purus, quis sagittis tortor sem sed tellus.
+          </p>
+
+          <p>
+            Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur faucibus nulla a nunc tincidunt semper.
+            Nam nibh lorem, pharetra ac ex ac, tempus fringilla est. Aenean tincidunt ipsum pellentesque, consequat
+            libero id, feugiat leo. In vestibulum faucibus velit, non tincidunt erat tincidunt in. Donec a diam sed nisl
+            convallis maximus. Aenean cursus sagittis lorem vitae tristique. Pellentesque pellentesque, quam eget
+            lobortis finibus, lectus lorem maximus purus, quis sagittis tortor sem sed tellus.
+          </p>
+        </div>
+      </ion-content>
+    </ion-app>
+  </body>
+</html>
diff --git a/core/src/components/item-sliding/test/scroll-target/item-sliding.e2e.ts b/core/src/components/item-sliding/test/scroll-target/item-sliding.e2e.ts
new file mode 100644
index 0000000000..162ed9105a
--- /dev/null
+++ b/core/src/components/item-sliding/test/scroll-target/item-sliding.e2e.ts
@@ -0,0 +1,38 @@
+import { expect } from '@playwright/test';
+import { test } from '@utils/test/playwright';
+
+test.describe('item-sliding: scroll-target', () => {
+  test('should not scroll when the item-sliding is swiped in custom scroll target', async ({
+    page,
+    browserName,
+  }, testInfo) => {
+    test.skip(browserName === 'webkit', 'mouse.wheel is not available in WebKit');
+    test.skip(testInfo.project.metadata.rtl === true, 'This feature does not have RTL-specific behaviors');
+
+    await page.goto(`/src/components/item-sliding/test/scroll-target`);
+
+    const itemSlidingEl = page.locator('ion-item-sliding');
+    const scrollEl = page.locator('.ion-content-scroll-host');
+
+    expect(await scrollEl.evaluate((el: HTMLElement) => el.scrollTop)).toEqual(0);
+
+    const box = (await itemSlidingEl.boundingBox())!;
+    const centerX = box.x + box.width / 2;
+    const centerY = box.y + box.height / 2;
+
+    await page.mouse.move(centerX, centerY);
+    await page.mouse.down();
+    await page.mouse.move(centerX - 30, centerY);
+
+    /**
+     * Do not use scrollToBottom() or other scrolling methods
+     * on ion-content as those will update the scroll position.
+     * Setting scrollTop still works even with overflow-y: hidden.
+     * However, simulating a user gesture should not scroll the content.
+     */
+    await page.mouse.wheel(0, 100);
+    await page.waitForChanges();
+
+    expect(await scrollEl.evaluate((el: HTMLElement) => el.scrollTop)).toEqual(0);
+  });
+});