diff --git a/core/api.txt b/core/api.txt
index b183a34d9c..61396d23c7 100644
--- a/core/api.txt
+++ b/core/api.txt
@@ -919,6 +919,7 @@ ion-infinite-scroll,none
 ion-infinite-scroll,prop,disabled,boolean,false,false,false
 ion-infinite-scroll,prop,mode,"ios" | "md",undefined,false,false
 ion-infinite-scroll,prop,position,"bottom" | "top",'bottom',false,false
+ion-infinite-scroll,prop,preserveRerenderScrollPosition,boolean,false,false,false
 ion-infinite-scroll,prop,theme,"ios" | "md" | "ionic",undefined,false,false
 ion-infinite-scroll,prop,threshold,string,'15%',false,false
 ion-infinite-scroll,method,complete,complete() => Promise<void>
diff --git a/core/src/components.d.ts b/core/src/components.d.ts
index 72f1d518f1..0109f7c693 100644
--- a/core/src/components.d.ts
+++ b/core/src/components.d.ts
@@ -1505,6 +1505,11 @@ export namespace Components {
           * @default 'bottom'
          */
         "position": 'top' | 'bottom';
+        /**
+          * If `true`, the infinite scroll will preserve the scroll position when the content is re-rendered. This is useful when the content is re-rendered with new keys, and the scroll position should be preserved.
+          * @default false
+         */
+        "preserveRerenderScrollPosition": boolean;
         /**
           * The theme determines the visual appearance of the component.
          */
@@ -7436,6 +7441,11 @@ declare namespace LocalJSX {
           * @default 'bottom'
          */
         "position"?: 'top' | 'bottom';
+        /**
+          * If `true`, the infinite scroll will preserve the scroll position when the content is re-rendered. This is useful when the content is re-rendered with new keys, and the scroll position should be preserved.
+          * @default false
+         */
+        "preserveRerenderScrollPosition"?: boolean;
         /**
           * The theme determines the visual appearance of the component.
          */
diff --git a/core/src/components/infinite-scroll/infinite-scroll.tsx b/core/src/components/infinite-scroll/infinite-scroll.tsx
index 291cdebb02..e2ec9d4277 100644
--- a/core/src/components/infinite-scroll/infinite-scroll.tsx
+++ b/core/src/components/infinite-scroll/infinite-scroll.tsx
@@ -16,6 +16,7 @@ export class InfiniteScroll implements ComponentInterface {
   private thrPx = 0;
   private thrPc = 0;
   private scrollEl?: HTMLElement;
+  private minHeightLocked = false;
 
   /**
    * didFire exists so that ionInfinite
@@ -80,6 +81,13 @@ export class InfiniteScroll implements ComponentInterface {
    */
   @Prop() position: 'top' | 'bottom' = 'bottom';
 
+  /**
+   * If `true`, the infinite scroll will preserve the scroll position
+   * when the content is re-rendered. This is useful when the content is
+   * re-rendered with new keys, and the scroll position should be preserved.
+   */
+  @Prop() preserveRerenderScrollPosition: boolean = false;
+
   /**
    * Emitted when the scroll reaches
    * the threshold distance. From within your infinite handler,
@@ -136,7 +144,16 @@ export class InfiniteScroll implements ComponentInterface {
       if (!this.didFire) {
         this.isLoading = true;
         this.didFire = true;
-        this.ionInfinite.emit();
+
+        if (this.preserveRerenderScrollPosition) {
+          // Lock the min height of the siblings of the infinite scroll
+          // if we are preserving the rerender scroll position
+          this.lockSiblingMinHeight(true).then(() => {
+            this.ionInfinite.emit();
+          });
+        } else {
+          this.ionInfinite.emit();
+        }
         return 3;
       }
     }
@@ -144,6 +161,55 @@ export class InfiniteScroll implements ComponentInterface {
     return 4;
   };
 
+  /**
+   * Loop through our sibling elements and lock or unlock their min height.
+   * This keeps our siblings, for example `ion-list`, the same height as their
+   * content currently is, so when it loads new data and the DOM removes the old
+   * data, the height of the container doesn't change and we don't lose our scroll position.
+   *
+   * We preserve existing min-height values, if they're set, so we don't erase what
+   * has been previously set by the user when we restore after complete is called.
+   */
+  private lockSiblingMinHeight(lock: boolean): Promise<void> {
+    return new Promise((resolve) => {
+      const siblings = this.el.parentElement?.children || [];
+      const writes: (() => void)[] = [];
+
+      for (const sibling of siblings) {
+        // Loop through all the siblings of the infinite scroll, but ignore ourself
+        if (sibling !== this.el && sibling instanceof HTMLElement) {
+          if (lock) {
+            const elementHeight = sibling.getBoundingClientRect().height;
+            writes.push(() => {
+              if (this.minHeightLocked) {
+                // The previous min height is from us locking it before, so we can disregard it
+                // We still need to lock the min height if we're already locked, though, because
+                // the user could have triggered a new load before we've finished the previous one.
+                const previousMinHeight = sibling.style.minHeight;
+                if (previousMinHeight) {
+                  sibling.style.setProperty('--ion-previous-min-height', previousMinHeight);
+                }
+              }
+              sibling.style.minHeight = `${elementHeight}px`;
+            });
+          } else {
+            writes.push(() => {
+              const previousMinHeight = sibling.style.getPropertyValue('--ion-previous-min-height');
+              sibling.style.minHeight = previousMinHeight || 'auto';
+              sibling.style.removeProperty('--ion-previous-min-height');
+            });
+          }
+        }
+      }
+
+      writeTask(() => {
+        writes.forEach((w) => w());
+        this.minHeightLocked = lock;
+        resolve();
+      });
+    });
+  }
+
   /**
    * Call `complete()` within the `ionInfinite` output event handler when
    * your async operation has completed. For example, the `loading`
@@ -208,6 +274,14 @@ export class InfiniteScroll implements ComponentInterface {
     } else {
       this.didFire = false;
     }
+
+    // Unlock the min height of the siblings of the infinite scroll
+    // if we are preserving the rerender scroll position
+    if (this.preserveRerenderScrollPosition) {
+      setTimeout(async () => {
+        await this.lockSiblingMinHeight(false);
+      }, 100);
+    }
   }
 
   private canStart(): boolean {
diff --git a/core/src/components/infinite-scroll/test/preserve-rerender-scroll-position/index.html b/core/src/components/infinite-scroll/test/preserve-rerender-scroll-position/index.html
new file mode 100644
index 0000000000..7e2768a571
--- /dev/null
+++ b/core/src/components/infinite-scroll/test/preserve-rerender-scroll-position/index.html
@@ -0,0 +1,129 @@
+<!DOCTYPE html>
+<html lang="en" dir="ltr">
+  <head>
+    <meta charset="UTF-8" />
+    <title>Infinite Scroll - Item Replacement</title>
+    <meta
+      name="viewport"
+      content="width=device-width, initial-scale=1.0, minimum-scale=1.0, maximum-scale=1.0, user-scalable=no"
+    />
+    <link href="../../../../../css/ionic.bundle.css" rel="stylesheet" />
+    <link href="../../../../../scripts/testing/styles.css" rel="stylesheet" />
+    <script src="../../../../../scripts/testing/scripts.js"></script>
+    <script nomodule src="../../../../../dist/ionic/ionic.js"></script>
+    <script type="module" src="../../../../../dist/ionic/ionic.esm.js"></script>
+  </head>
+
+  <body>
+    <ion-app>
+      <ion-header>
+        <ion-toolbar>
+          <ion-title>Infinite Scroll - Item Replacement</ion-title>
+        </ion-toolbar>
+      </ion-header>
+
+      <ion-content class="ion-padding" id="content">
+        <IonHeader collapse="condense">
+          <IonToolbar>
+            <IonTitle size="large">Title</IonTitle>
+          </IonToolbar>
+        </IonHeader>
+
+        <div className="ion-padding">Scroll the list to see the title collapse.</div>
+
+        <ion-list id="list"></ion-list>
+
+        <ion-infinite-scroll threshold="100px" id="infinite-scroll" preserve-rerender-scroll-position>
+          <ion-infinite-scroll-content loading-spinner="crescent" loading-text="Loading more data...">
+          </ion-infinite-scroll-content>
+        </ion-infinite-scroll>
+      </ion-content>
+    </ion-app>
+
+    <script>
+      const list = document.getElementById('list');
+      const infiniteScroll = document.getElementById('infinite-scroll');
+      const content = document.getElementById('content');
+      const scrollPositionDiv = document.getElementById('scroll-position');
+      const modeDiv = document.getElementById('mode');
+      let loading = false;
+      let itemCount = 0;
+      let generationCount = 0;
+
+      // Track scroll position for debugging
+      content.addEventListener('ionScroll', () => {
+        const scrollTop = content.scrollTop;
+        scrollPositionDiv.textContent = `Scroll Position: ${scrollTop}`;
+      });
+
+      infiniteScroll.addEventListener('ionInfinite', async function () {
+        // Save current scroll position before replacement
+        const currentScrollTop = content.scrollTop;
+        window.currentScrollBeforeReplace = currentScrollTop;
+        console.log('loading', loading);
+        if (loading) {
+          infiniteScroll.complete();
+          return;
+        }
+        loading = true;
+
+        replaceAllItems();
+        infiniteScroll.complete();
+
+        window.dispatchEvent(
+          new CustomEvent('ionInfiniteComplete', {
+            detail: {
+              scrollTopBefore: currentScrollTop,
+              scrollTopAfter: content.scrollTop,
+              generation: generationCount,
+              mode: 'normal',
+            },
+          })
+        );
+
+        setTimeout(() => {
+          console.log('setting loading to false');
+          loading = false;
+        });
+      });
+
+      function replaceAllItems() {
+        console.log('replaceAllItems');
+        // This simulates what happens in React when all items get new keys
+        // Clear all existing items
+        list.innerHTML = '';
+
+        generationCount++;
+        const generation = generationCount;
+
+        // Add new items with new "keys" (different content/identifiers)
+        // Start with more items to ensure scrollable content
+        const totalItems = generation === 1 ? 50 : 30 + generation * 20;
+        itemCount = 0;
+
+        for (let i = 0; i < totalItems; i++) {
+          const el = document.createElement('ion-item');
+          el.setAttribute('data-key', `gen-${generation}-item-${i}`);
+          el.setAttribute('data-generation', generation);
+          el.textContent = `Gen ${generation} - Item ${
+            i + 1
+          } - Additional content to make this item taller and ensure scrolling`;
+          el.id = `item-gen-${generation}-${i}`;
+          list.appendChild(el);
+          itemCount++;
+        }
+      }
+
+      function wait(time) {
+        return new Promise((resolve) => {
+          setTimeout(() => {
+            resolve();
+          }, time);
+        });
+      }
+
+      // Initial load
+      replaceAllItems();
+    </script>
+  </body>
+</html>
diff --git a/core/src/components/infinite-scroll/test/preserve-rerender-scroll-position/infinite-scroll.e2e.ts b/core/src/components/infinite-scroll/test/preserve-rerender-scroll-position/infinite-scroll.e2e.ts
new file mode 100644
index 0000000000..8605b580e0
--- /dev/null
+++ b/core/src/components/infinite-scroll/test/preserve-rerender-scroll-position/infinite-scroll.e2e.ts
@@ -0,0 +1,32 @@
+import { expect } from '@playwright/test';
+import { configs, test } from '@utils/test/playwright';
+
+test.setTimeout(100000);
+
+configs({ modes: ['md'], directions: ['ltr'] }).forEach(({ title, config }) => {
+  test.describe(title('infinite-scroll: preserve rerender scroll position'), () => {
+    test('should load more items when scrolled to the bottom', async ({ page }) => {
+      await page.goto('/src/components/infinite-scroll/test/preserve-rerender-scroll-position', config);
+
+      const ionInfiniteComplete = await page.spyOnEvent('ionInfiniteComplete');
+      const content = page.locator('ion-content');
+      const items = page.locator('ion-item');
+      const innerScroll = page.locator('.inner-scroll');
+      expect(await items.count()).toBe(50);
+
+      let previousScrollTop = 0;
+      for (let i = 0; i < 30; i++) {
+        await content.evaluate((el: HTMLIonContentElement) => el.scrollToBottom(0));
+        const currentScrollTop = await innerScroll.evaluate((el: HTMLIonContentElement) => el.scrollTop);
+        expect(currentScrollTop).toBeGreaterThan(previousScrollTop);
+        await ionInfiniteComplete.next();
+        const newScrollTop = await innerScroll.evaluate((el: HTMLIonContentElement) => el.scrollTop);
+        console.log(`Scroll position should be preserved after ${i + 1} iterations`, newScrollTop, previousScrollTop);
+        expect(newScrollTop, `Scroll position should be preserved after ${i + 1} iterations`).toBeGreaterThanOrEqual(
+          previousScrollTop
+        );
+        previousScrollTop = currentScrollTop;
+      }
+    });
+  });
+});
diff --git a/packages/angular/src/directives/proxies.ts b/packages/angular/src/directives/proxies.ts
index ae0bdafac3..907390819e 100644
--- a/packages/angular/src/directives/proxies.ts
+++ b/packages/angular/src/directives/proxies.ts
@@ -927,7 +927,7 @@ export declare interface IonImg extends Components.IonImg {
 
 
 @ProxyCmp({
-  inputs: ['disabled', 'mode', 'position', 'theme', 'threshold'],
+  inputs: ['disabled', 'mode', 'position', 'preserveRerenderScrollPosition', 'theme', 'threshold'],
   methods: ['complete']
 })
 @Component({
@@ -935,7 +935,7 @@ export declare interface IonImg extends Components.IonImg {
   changeDetection: ChangeDetectionStrategy.OnPush,
   template: '<ng-content></ng-content>',
   // eslint-disable-next-line @angular-eslint/no-inputs-metadata-property
-  inputs: ['disabled', 'mode', 'position', 'theme', 'threshold'],
+  inputs: ['disabled', 'mode', 'position', 'preserveRerenderScrollPosition', 'theme', 'threshold'],
 })
 export class IonInfiniteScroll {
   protected el: HTMLIonInfiniteScrollElement;
diff --git a/packages/angular/standalone/src/directives/proxies.ts b/packages/angular/standalone/src/directives/proxies.ts
index 590555cdc8..56b308e25b 100644
--- a/packages/angular/standalone/src/directives/proxies.ts
+++ b/packages/angular/standalone/src/directives/proxies.ts
@@ -952,7 +952,7 @@ export declare interface IonImg extends Components.IonImg {
 
 @ProxyCmp({
   defineCustomElementFn: defineIonInfiniteScroll,
-  inputs: ['disabled', 'mode', 'position', 'theme', 'threshold'],
+  inputs: ['disabled', 'mode', 'position', 'preserveRerenderScrollPosition', 'theme', 'threshold'],
   methods: ['complete']
 })
 @Component({
@@ -960,7 +960,7 @@ export declare interface IonImg extends Components.IonImg {
   changeDetection: ChangeDetectionStrategy.OnPush,
   template: '<ng-content></ng-content>',
   // eslint-disable-next-line @angular-eslint/no-inputs-metadata-property
-  inputs: ['disabled', 'mode', 'position', 'theme', 'threshold'],
+  inputs: ['disabled', 'mode', 'position', 'preserveRerenderScrollPosition', 'theme', 'threshold'],
   standalone: true
 })
 export class IonInfiniteScroll {
diff --git a/packages/vue/src/proxies.ts b/packages/vue/src/proxies.ts
index 6e9dace0e2..0dd1a1f706 100644
--- a/packages/vue/src/proxies.ts
+++ b/packages/vue/src/proxies.ts
@@ -455,6 +455,7 @@ export const IonInfiniteScroll: StencilVueComponent<JSX.IonInfiniteScroll> = /*@
   'threshold',
   'disabled',
   'position',
+  'preserveRerenderScrollPosition',
   'ionInfinite'
 ], [
   'ionInfinite'