diff --git a/core/src/components.d.ts b/core/src/components.d.ts
index 81ccd9db23..14d14454de 100644
--- a/core/src/components.d.ts
+++ b/core/src/components.d.ts
@@ -2043,6 +2043,10 @@ export namespace Components {
           * The color to use from your application's color palette. Default options are: `"primary"`, `"secondary"`, `"tertiary"`, `"success"`, `"warning"`, `"danger"`, `"light"`, `"medium"`, and `"dark"`. For more information on colors, see [theming](/docs/theming/basics).
          */
         "color"?: Color;
+        /**
+          * If `true`, the user cannot interact with the picker.
+         */
+        "disabled": boolean;
         /**
           * A list of options to be displayed in the picker
          */
@@ -6683,6 +6687,10 @@ declare namespace LocalJSX {
           * The color to use from your application's color palette. Default options are: `"primary"`, `"secondary"`, `"tertiary"`, `"success"`, `"warning"`, `"danger"`, `"light"`, `"medium"`, and `"dark"`. For more information on colors, see [theming](/docs/theming/basics).
          */
         "color"?: Color;
+        /**
+          * If `true`, the user cannot interact with the picker.
+         */
+        "disabled"?: boolean;
         /**
           * A list of options to be displayed in the picker
          */
diff --git a/core/src/components/datetime/datetime.tsx b/core/src/components/datetime/datetime.tsx
index d2c6cd6d0b..599dd718d1 100644
--- a/core/src/components/datetime/datetime.tsx
+++ b/core/src/components/datetime/datetime.tsx
@@ -1538,7 +1538,7 @@ export class Datetime implements ComponentInterface {
   }
 
   private renderCombinedDatePickerColumn() {
-    const { defaultParts, workingParts, locale, minParts, maxParts, todayParts, isDateEnabled } = this;
+    const { defaultParts, disabled, workingParts, locale, minParts, maxParts, todayParts, isDateEnabled } = this;
 
     const activePart = this.getActivePartsWithFallback();
 
@@ -1617,6 +1617,7 @@ export class Datetime implements ComponentInterface {
       <ion-picker-column-internal
         class="date-column"
         color={this.color}
+        disabled={disabled}
         items={items}
         value={todayString}
         onIonChange={(ev: CustomEvent) => {
@@ -1728,7 +1729,7 @@ export class Datetime implements ComponentInterface {
       return [];
     }
 
-    const { workingParts } = this;
+    const { disabled, workingParts } = this;
 
     const activePart = this.getActivePartsWithFallback();
 
@@ -1736,6 +1737,7 @@ export class Datetime implements ComponentInterface {
       <ion-picker-column-internal
         class="day-column"
         color={this.color}
+        disabled={disabled}
         items={days}
         value={(workingParts.day !== null ? workingParts.day : this.defaultParts.day) ?? undefined}
         onIonChange={(ev: CustomEvent) => {
@@ -1772,7 +1774,7 @@ export class Datetime implements ComponentInterface {
       return [];
     }
 
-    const { workingParts } = this;
+    const { disabled, workingParts } = this;
 
     const activePart = this.getActivePartsWithFallback();
 
@@ -1780,6 +1782,7 @@ export class Datetime implements ComponentInterface {
       <ion-picker-column-internal
         class="month-column"
         color={this.color}
+        disabled={disabled}
         items={months}
         value={workingParts.month}
         onIonChange={(ev: CustomEvent) => {
@@ -1815,7 +1818,7 @@ export class Datetime implements ComponentInterface {
       return [];
     }
 
-    const { workingParts } = this;
+    const { disabled, workingParts } = this;
 
     const activePart = this.getActivePartsWithFallback();
 
@@ -1823,6 +1826,7 @@ export class Datetime implements ComponentInterface {
       <ion-picker-column-internal
         class="year-column"
         color={this.color}
+        disabled={disabled}
         items={years}
         value={workingParts.year}
         onIonChange={(ev: CustomEvent) => {
@@ -1888,7 +1892,7 @@ export class Datetime implements ComponentInterface {
   }
 
   private renderHourPickerColumn(hoursData: PickerColumnItem[]) {
-    const { workingParts } = this;
+    const { disabled, workingParts } = this;
     if (hoursData.length === 0) return [];
 
     const activePart = this.getActivePartsWithFallback();
@@ -1896,6 +1900,7 @@ export class Datetime implements ComponentInterface {
     return (
       <ion-picker-column-internal
         color={this.color}
+        disabled={disabled}
         value={activePart.hour}
         items={hoursData}
         numericInput
@@ -1916,7 +1921,7 @@ export class Datetime implements ComponentInterface {
     );
   }
   private renderMinutePickerColumn(minutesData: PickerColumnItem[]) {
-    const { workingParts } = this;
+    const { disabled, workingParts } = this;
     if (minutesData.length === 0) return [];
 
     const activePart = this.getActivePartsWithFallback();
@@ -1924,6 +1929,7 @@ export class Datetime implements ComponentInterface {
     return (
       <ion-picker-column-internal
         color={this.color}
+        disabled={disabled}
         value={activePart.minute}
         items={minutesData}
         numericInput
@@ -1944,7 +1950,7 @@ export class Datetime implements ComponentInterface {
     );
   }
   private renderDayPeriodPickerColumn(dayPeriodData: PickerColumnItem[]) {
-    const { workingParts } = this;
+    const { disabled, workingParts } = this;
     if (dayPeriodData.length === 0) {
       return [];
     }
@@ -1956,6 +1962,7 @@ export class Datetime implements ComponentInterface {
       <ion-picker-column-internal
         style={isDayPeriodRTL ? { order: '-1' } : {}}
         color={this.color}
+        disabled={disabled}
         value={activePart.ampm}
         items={dayPeriodData}
         onIonChange={(ev: CustomEvent) => {
diff --git a/core/src/components/datetime/test/disabled/datetime.spec.tsx b/core/src/components/datetime/test/disabled/datetime.spec.tsx
new file mode 100644
index 0000000000..9d6f6c8553
--- /dev/null
+++ b/core/src/components/datetime/test/disabled/datetime.spec.tsx
@@ -0,0 +1,39 @@
+import { h } from '@stencil/core';
+import { newSpecPage } from '@stencil/core/testing';
+
+import { Datetime } from '../../../datetime/datetime';
+import { PickerColumnInternal } from '../../../picker-column-internal/picker-column-internal';
+import { PickerInternal } from '../../../picker-internal/picker-internal';
+
+describe('ion-datetime disabled', () => {
+  beforeEach(() => {
+    // IntersectionObserver isn't available in test environment
+    const mockIntersectionObserver = jest.fn();
+    mockIntersectionObserver.mockReturnValue({
+      observe: () => null,
+      unobserve: () => null,
+      disconnect: () => null,
+    });
+    global.IntersectionObserver = mockIntersectionObserver;
+  });
+
+  it('picker should be disabled in prefer wheel mode', async () => {
+    const page = await newSpecPage({
+      components: [Datetime, PickerColumnInternal, PickerInternal],
+      template: () => (
+        <ion-datetime id="inline-datetime-wheel" disabled prefer-wheel value="2022-04-21T00:00:00"></ion-datetime>
+      ),
+    });
+
+    await page.waitForChanges();
+
+    const datetime = page.body.querySelector('ion-datetime')!;
+    const columns = datetime.shadowRoot!.querySelectorAll('ion-picker-column-internal');
+
+    await expect(columns.length).toEqual(4);
+
+    columns.forEach((column) => {
+      expect(column.disabled).toBe(true);
+    });
+  });
+});
diff --git a/core/src/components/datetime/test/disabled/index.html b/core/src/components/datetime/test/disabled/index.html
index 764d3a42ca..b0a8ac364b 100644
--- a/core/src/components/datetime/test/disabled/index.html
+++ b/core/src/components/datetime/test/disabled/index.html
@@ -66,6 +66,11 @@
             <h2>Inline - No Default Value</h2>
             <ion-datetime id="inline-datetime-no-value" disabled></ion-datetime>
           </div>
+
+          <div class="grid-item">
+            <h2>Inline - Prefer Wheel</h2>
+            <ion-datetime id="inline-datetime-wheel" disabled prefer-wheel value="2022-04-21T00:00:00"></ion-datetime>
+          </div>
         </div>
       </ion-content>
       <script>
diff --git a/core/src/components/picker-column-internal/picker-column-internal.scss b/core/src/components/picker-column-internal/picker-column-internal.scss
index 6e9c2a7375..7d6eef98cc 100644
--- a/core/src/components/picker-column-internal/picker-column-internal.scss
+++ b/core/src/components/picker-column-internal/picker-column-internal.scss
@@ -71,13 +71,20 @@
 }
 
 :host .picker-item-empty,
-:host .picker-item.picker-item-disabled {
-  scroll-snap-align: none;
-
+:host .picker-item[disabled] {
   cursor: default;
 }
 
-:host .picker-item.picker-item-disabled {
+:host .picker-item-empty,
+:host(:not([disabled])) .picker-item[disabled] {
+  scroll-snap-align: none;
+}
+
+:host([disabled]) {
+  overflow-y: hidden;
+}
+
+:host .picker-item[disabled] {
   opacity: 0.4;
 }
 
diff --git a/core/src/components/picker-column-internal/picker-column-internal.tsx b/core/src/components/picker-column-internal/picker-column-internal.tsx
index 01a152ee98..73b8dd3435 100644
--- a/core/src/components/picker-column-internal/picker-column-internal.tsx
+++ b/core/src/components/picker-column-internal/picker-column-internal.tsx
@@ -35,6 +35,11 @@ export class PickerColumnInternal implements ComponentInterface {
 
   @Element() el!: HTMLIonPickerColumnInternalElement;
 
+  /**
+   * If `true`, the user cannot interact with the picker.
+   */
+  @Prop() disabled = false;
+
   /**
    * A list of options to be displayed in the picker
    */
@@ -408,13 +413,15 @@ export class PickerColumnInternal implements ComponentInterface {
   };
 
   get activeItem() {
-    return getElementRoot(this.el).querySelector(
-      `.picker-item[data-value="${this.value}"]:not([disabled])`
-    ) as HTMLElement | null;
+    // If the whole picker column is disabled, the current value should appear active
+    // If the current value item is specifically disabled, it should not appear active
+    const selector = `.picker-item[data-value="${this.value}"]${this.disabled ? '' : ':not([disabled])'}`;
+
+    return getElementRoot(this.el).querySelector(selector) as HTMLElement | null;
   }
 
   render() {
-    const { items, color, isActive, numericInput } = this;
+    const { items, color, disabled: pickerDisabled, isActive, numericInput } = this;
     const mode = getIonMode(this);
 
     /**
@@ -423,10 +430,12 @@ export class PickerColumnInternal implements ComponentInterface {
      * the attribute can be moved to datetime.tsx and set on every
      * instance of ion-picker-column-internal there instead.
      */
+
     return (
       <Host
         exportparts={`${PICKER_ITEM_PART}, ${PICKER_ITEM_ACTIVE_PART}`}
-        tabindex={0}
+        disabled={pickerDisabled}
+        tabindex={pickerDisabled ? null : 0}
         class={createColorClasses(color, {
           [mode]: true,
           ['picker-column-active']: isActive,
@@ -443,6 +452,8 @@ export class PickerColumnInternal implements ComponentInterface {
           &nbsp;
         </div>
         {items.map((item, index) => {
+          const isItemDisabled = pickerDisabled || item.disabled || false;
+
           {
             /*
             Users should be able to tab
@@ -458,14 +469,13 @@ export class PickerColumnInternal implements ComponentInterface {
               tabindex="-1"
               class={{
                 'picker-item': true,
-                'picker-item-disabled': item.disabled || false,
               }}
               data-value={item.value}
               data-index={index}
               onClick={(ev: Event) => {
                 this.centerPickerItemInView(ev.target as HTMLElement, true);
               }}
-              disabled={item.disabled}
+              disabled={isItemDisabled}
               part={PICKER_ITEM_PART}
             >
               {item.text}
diff --git a/core/src/components/picker-column-internal/test/disabled/index.html b/core/src/components/picker-column-internal/test/disabled/index.html
index 5ff9b28f37..fbfad1c540 100644
--- a/core/src/components/picker-column-internal/test/disabled/index.html
+++ b/core/src/components/picker-column-internal/test/disabled/index.html
@@ -45,26 +45,39 @@
       <ion-content class="ion-padding">
         <div class="grid">
           <div class="grid-item">
-            <h2>Default</h2>
+            <h2>Even items disabled</h2>
             <ion-picker-internal>
-              <ion-picker-column-internal id="default"></ion-picker-column-internal>
+              <ion-picker-column-internal id="half-disabled"></ion-picker-column-internal>
+            </ion-picker-internal>
+          </div>
+          <div class="grid-item">
+            <h2>Column disabled</h2>
+            <ion-picker-internal>
+              <ion-picker-column-internal id="column-disabled" value="11" disabled></ion-picker-column-internal>
             </ion-picker-internal>
           </div>
         </div>
       </ion-content>
       <script>
-        const defaultPickerColumn = document.getElementById('default');
-
-        const items = Array(24)
+        const halfDisabledPicker = document.getElementById('half-disabled');
+        const halfDisabledItems = Array(24)
           .fill()
           .map((_, i) => ({
             text: `${i}`,
             value: i,
             disabled: i % 2 === 0,
           }));
+        halfDisabledPicker.items = halfDisabledItems;
+        halfDisabledPicker.value = 12;
 
-        defaultPickerColumn.items = items;
-        defaultPickerColumn.value = 12;
+        const fullDisabledPicker = document.getElementById('column-disabled');
+        const items = Array(24)
+          .fill()
+          .map((_, i) => ({
+            text: `${i}`,
+            value: i,
+          }));
+        fullDisabledPicker.items = items;
       </script>
     </ion-app>
   </body>
diff --git a/core/src/components/picker-column-internal/test/disabled/picker-column-internal.e2e.ts b/core/src/components/picker-column-internal/test/disabled/picker-column-internal.e2e.ts
index 9629f4345d..5e6464c22a 100644
--- a/core/src/components/picker-column-internal/test/disabled/picker-column-internal.e2e.ts
+++ b/core/src/components/picker-column-internal/test/disabled/picker-column-internal.e2e.ts
@@ -35,7 +35,7 @@ configs({ directions: ['ltr'] }).forEach(({ title, screenshot, config }) => {
  * This behavior does not vary across modes/directions.
  */
 configs({ modes: ['ios'], directions: ['ltr'] }).forEach(({ title, config }) => {
-  test.describe(title('picker-column-internal: disabled'), () => {
+  test.describe(title('picker-column-internal: disabled items'), () => {
     test('all picker items should be enabled by default', async ({ page }) => {
       await page.setContent(
         `
@@ -55,9 +55,7 @@ configs({ modes: ['ios'], directions: ['ltr'] }).forEach(({ title, config }) =>
         config
       );
 
-      const pickerItems = page.locator(
-        'ion-picker-column-internal .picker-item:not(.picker-item-empty, .picker-item-disabled)'
-      );
+      const pickerItems = page.locator('ion-picker-column-internal .picker-item:not(.picker-item-empty, [disabled])');
 
       expect(await pickerItems.count()).toBe(3);
     });
@@ -80,7 +78,7 @@ configs({ modes: ['ios'], directions: ['ltr'] }).forEach(({ title, config }) =>
         config
       );
 
-      const disabledItem = page.locator('ion-picker-column-internal .picker-item.picker-item-disabled');
+      const disabledItem = page.locator('ion-picker-column-internal .picker-item[disabled]');
       await expect(disabledItem).not.toBeEnabled();
     });
     test('disabled picker item should not be considered active', async ({ page }) => {
@@ -130,7 +128,7 @@ configs({ modes: ['ios'], directions: ['ltr'] }).forEach(({ title, config }) =>
       await page.waitForChanges();
 
       const disabledItem = page.locator('ion-picker-column-internal .picker-item[data-value="b"]');
-      await expect(disabledItem).toHaveClass(/picker-item-disabled/);
+      await expect(disabledItem).toBeDisabled();
       await expect(disabledItem).not.toHaveClass(/picker-item-active/);
     });
     test('defaulting the value to a disabled item should not cause that item to be active', async ({ page }) => {
@@ -154,8 +152,42 @@ configs({ modes: ['ios'], directions: ['ltr'] }).forEach(({ title, config }) =>
       );
 
       const disabledItem = page.locator('ion-picker-column-internal .picker-item[data-value="b"]');
-      await expect(disabledItem).toHaveClass(/picker-item-disabled/);
+      await expect(disabledItem).toBeDisabled();
       await expect(disabledItem).not.toHaveClass(/picker-item-active/);
     });
   });
 });
+
+/**
+ * This behavior does not vary across directions.
+ */
+configs({ directions: ['ltr'] }).forEach(({ title, screenshot, config }) => {
+  test.describe(title('picker-column-internal: disabled column rendering'), () => {
+    test.beforeEach(async ({ page }) => {
+      await page.goto('/src/components/picker-column-internal/test/disabled', config);
+    });
+
+    test('disabled column should not have visual regressions', async ({ page }) => {
+      const disabledColumn = page.locator('#column-disabled');
+      await page.waitForChanges();
+
+      await expect(disabledColumn).toHaveScreenshot(screenshot('picker-internal-disabled-column'));
+    });
+  });
+});
+
+/**
+ * This behavior does not vary across modes/directions.
+ */
+configs({ modes: ['ios'], directions: ['ltr'] }).forEach(({ title, config }) => {
+  test.describe(title('picker-column-internal: disabled column'), () => {
+    test.beforeEach(async ({ page }) => {
+      await page.goto('/src/components/picker-column-internal/test/disabled', config);
+    });
+
+    test('item in disabled column should not be interactive', async ({ page }) => {
+      const secondItem = page.locator('#column-disabled .picker-item:not(.picker-item-empty)').nth(1);
+      await expect(secondItem).toBeDisabled();
+    });
+  });
+});
diff --git a/core/src/components/picker-column-internal/test/disabled/picker-column-internal.e2e.ts-snapshots/picker-internal-disabled-column-ios-ltr-Mobile-Chrome-linux.png b/core/src/components/picker-column-internal/test/disabled/picker-column-internal.e2e.ts-snapshots/picker-internal-disabled-column-ios-ltr-Mobile-Chrome-linux.png
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