diff --git a/script/tool/CHANGELOG.md b/script/tool/CHANGELOG.md
index dc30c05f79..7d1eac01b7 100644
--- a/script/tool/CHANGELOG.md
+++ b/script/tool/CHANGELOG.md
@@ -1,5 +1,9 @@
 ## NEXT
 
+- `--exclude` and `--custom-analysis` now accept paths to YAML files that
+  contain lists of packages to exclude, in addition to just package names,
+  so that exclude lists can be maintained separately from scripts and CI
+  configuration.
 - Added an `xctest` flag to select specific test targets, to allow running only
   unit tests or integration tests.
 - **Breaking change**: Split Xcode analysis out of `xctest` and into a new
diff --git a/script/tool/lib/src/analyze_command.dart b/script/tool/lib/src/analyze_command.dart
index e56b95d88e..4fd15f027f 100644
--- a/script/tool/lib/src/analyze_command.dart
+++ b/script/tool/lib/src/analyze_command.dart
@@ -6,6 +6,7 @@ import 'dart:async';
 
 import 'package:file/file.dart';
 import 'package:platform/platform.dart';
+import 'package:yaml/yaml.dart';
 
 import 'common/core.dart';
 import 'common/package_looping_command.dart';
@@ -23,7 +24,10 @@ class AnalyzeCommand extends PackageLoopingCommand {
   }) : super(packagesDir, processRunner: processRunner, platform: platform) {
     argParser.addMultiOption(_customAnalysisFlag,
         help:
-            'Directories (comma separated) that are allowed to have their own analysis options.',
+            'Directories (comma separated) that are allowed to have their own '
+            'analysis options.\n\n'
+            'Alternately, a list of one or more YAML files that contain a list '
+            'of allowed directories.',
         defaultsTo: <String>[]);
     argParser.addOption(_analysisSdk,
         valueHelp: 'dart-sdk',
@@ -37,6 +41,8 @@ class AnalyzeCommand extends PackageLoopingCommand {
 
   late String _dartBinaryPath;
 
+  Set<String> _allowedCustomAnalysisDirectories = const <String>{};
+
   @override
   final String name = 'analyze';
 
@@ -56,7 +62,7 @@ class AnalyzeCommand extends PackageLoopingCommand {
         continue;
       }
 
-      final bool allowed = (getStringListArg(_customAnalysisFlag)).any(
+      final bool allowed = _allowedCustomAnalysisDirectories.any(
           (String directory) =>
               directory.isNotEmpty &&
               path.isWithin(
@@ -107,6 +113,17 @@ class AnalyzeCommand extends PackageLoopingCommand {
       throw ToolExit(_exitPackagesGetFailed);
     }
 
+    _allowedCustomAnalysisDirectories =
+        getStringListArg(_customAnalysisFlag).expand<String>((String item) {
+      if (item.endsWith('.yaml')) {
+        final File file = packagesDir.fileSystem.file(item);
+        return (loadYaml(file.readAsStringSync()) as YamlList)
+            .toList()
+            .cast<String>();
+      }
+      return <String>[item];
+    }).toSet();
+
     // Use the Dart SDK override if one was passed in.
     final String? dartSdk = argResults![_analysisSdk] as String?;
     _dartBinaryPath =
diff --git a/script/tool/lib/src/common/plugin_command.dart b/script/tool/lib/src/common/plugin_command.dart
index ecdcb0565d..7781eee0d9 100644
--- a/script/tool/lib/src/common/plugin_command.dart
+++ b/script/tool/lib/src/common/plugin_command.dart
@@ -9,6 +9,7 @@ import 'package:file/file.dart';
 import 'package:git/git.dart';
 import 'package:path/path.dart' as p;
 import 'package:platform/platform.dart';
+import 'package:yaml/yaml.dart';
 
 import 'core.dart';
 import 'git_version_finder.dart';
@@ -48,7 +49,9 @@ abstract class PluginCommand extends Command<void> {
     argParser.addMultiOption(
       _excludeArg,
       abbr: 'e',
-      help: 'Exclude packages from this command.',
+      help: 'A list of packages to exclude from from this command.\n\n'
+          'Alternately, a list of one or more YAML files that contain a list '
+          'of packages to exclude.',
       defaultsTo: <String>[],
     );
     argParser.addFlag(_runOnChangedPackagesArg,
@@ -214,8 +217,18 @@ abstract class PluginCommand extends Command<void> {
   ///    of packages in the flutter/packages repository.
   Stream<Directory> _getAllPlugins() async* {
     Set<String> plugins = Set<String>.from(getStringListArg(_packagesArg));
+
     final Set<String> excludedPlugins =
-        Set<String>.from(getStringListArg(_excludeArg));
+        getStringListArg(_excludeArg).expand<String>((String item) {
+      if (item.endsWith('.yaml')) {
+        final File file = packagesDir.fileSystem.file(item);
+        return (loadYaml(file.readAsStringSync()) as YamlList)
+            .toList()
+            .cast<String>();
+      }
+      return <String>[item];
+    }).toSet();
+
     final bool runOnChangedPackages = getBoolArg(_runOnChangedPackagesArg);
     if (plugins.isEmpty &&
         runOnChangedPackages &&
diff --git a/script/tool/test/analyze_command_test.dart b/script/tool/test/analyze_command_test.dart
index 69a2c4f955..9dc8b6a3fc 100644
--- a/script/tool/test/analyze_command_test.dart
+++ b/script/tool/test/analyze_command_test.dart
@@ -176,6 +176,25 @@ void main() {
           ]));
     });
 
+    test('takes an allow config file', () async {
+      final Directory pluginDir = createFakePlugin('foo', packagesDir,
+          extraFiles: <String>['analysis_options.yaml']);
+      final File allowFile = packagesDir.childFile('custom.yaml');
+      allowFile.writeAsStringSync('- foo');
+
+      await runCapturingPrint(
+          runner, <String>['analyze', '--custom-analysis', allowFile.path]);
+
+      expect(
+          processRunner.recordedCalls,
+          orderedEquals(<ProcessCall>[
+            ProcessCall(
+                'flutter', const <String>['packages', 'get'], pluginDir.path),
+            ProcessCall('dart', const <String>['analyze', '--fatal-infos'],
+                pluginDir.path),
+          ]));
+    });
+
     // See: https://github.com/flutter/flutter/issues/78994
     test('takes an empty allow list', () async {
       createFakePlugin('foo', packagesDir,
diff --git a/script/tool/test/common/plugin_command_test.dart b/script/tool/test/common/plugin_command_test.dart
index fdab9612be..7f67acfb2d 100644
--- a/script/tool/test/common/plugin_command_test.dart
+++ b/script/tool/test/common/plugin_command_test.dart
@@ -172,6 +172,19 @@ void main() {
       expect(plugins, unorderedEquals(<String>[plugin2.path]));
     });
 
+    test('exclude accepts config files', () async {
+      createFakePlugin('plugin1', packagesDir);
+      final File configFile = packagesDir.childFile('exclude.yaml');
+      configFile.writeAsStringSync('- plugin1');
+
+      await runCapturingPrint(runner, <String>[
+        'sample',
+        '--packages=plugin1',
+        '--exclude=${configFile.path}'
+      ]);
+      expect(plugins, unorderedEquals(<String>[]));
+    });
+
     group('test run-on-changed-packages', () {
       test('all plugins should be tested if there are no changes.', () async {
         final Directory plugin1 = createFakePlugin('plugin1', packagesDir);