diff --git a/gdb/ChangeLog b/gdb/ChangeLog
index 10c9c05183d..f9dc6f9c61f 100644
--- a/gdb/ChangeLog
+++ b/gdb/ChangeLog
@@ -1,3 +1,9 @@
+2016-06-01  Yao Qi  <yao.qi@linaro.org>
+
+	PR remote/19998
+	* remote-fileio.c (remote_fileio_ctrl_c_signal_handler): Call
+	quit_serial_event_set.
+
 2016-06-01  Joel Brobecker  <brobecker@adacore.com>
 
 	GDB 7.11.1 released.
diff --git a/gdb/remote-fileio.c b/gdb/remote-fileio.c
index 44817df37b7..29c5ca35896 100644
--- a/gdb/remote-fileio.c
+++ b/gdb/remote-fileio.c
@@ -348,6 +348,8 @@ remote_fileio_ctrl_c_signal_handler (int signo)
 {
   remote_fileio_sig_set (remote_fileio_ctrl_c_signal_handler);
   remote_fio_ctrl_c_flag = 1;
+  /* Wake up interruptible_select.  */
+  quit_serial_event_set ();
 }
 
 static void